3.0
Summary
| Name |  NLKView Modifications |
| Full Name | Serine/threonine-protein kinase NLK |
| Synonyms | Nemo-like kinase, Protein LAK1 | LAK1 |
| Primary ID | Q9UBE8 |
| Links |  -  -  |
| Type | protein |
| Relations | 15 |
| Function | Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Negative regulator of the canonical Wnt/beta-catenin signaling pathway. Binds to and phosphorylates TCF7L2/TCF4 and LEF1, promoting the dissociation of the TCF7L2/LEF1/beta-catenin complex from DNA, as well as the ubiquitination and subsequent proteolysis of LEF1. Together these effects inhibit the transcriptional activation of canonical Wnt/beta-catenin target genes. Negative regulator of the Notch signaling pathway. Binds to and phosphorylates NOTCH1, thereby preventing the formation of a transcriptionally active ternary complex of NOTCH1, RBPJ/RBPSUH and MAML1. Negative regulator of the MYB family of transcription factors. Phosphorylation of MYB leads to its subsequent proteolysis while phosphorylation of MYBL1 and MYBL2 inhibits their interaction with the coactivator CREBBP. Other transcription factors may also be inhibited by direct phosphorylation of CREBBP itself. Acts downstream of IL6 and MAP3K7/TAK1 to phosphorylate STAT3, which is in turn required for activation of NLK by MAP3K7/TAK1. Upon IL1B stimulus, cooperates with ATF5 to activate the transactivation activity of C/EBP subfamily members. Phosphorylates ATF5 but also stabilizes ATF5 protein levels in a kinase-independent manner (PubMed:25512613). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | NLK | up-regulates activity 
phosphorylation
|
YAP1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NLK | down-regulates 
phosphorylation
|
LEF1 | 0.75 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | NLK | down-regulates activity
phosphorylation
|
FOXO1 | 0.599 |
| Publications: | 1 | Organism: | Chlorocebus Aethiops | |
| + | NLK | up-regulates
phosphorylation
|
STAT3 | 0.355 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NLK | down-regulates activity
phosphorylation
|
RPTOR | 0.338 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NLK | down-regulates
phosphorylation
|
TCF7L2 | 0.763 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | NLK | down-regulates quantity
phosphorylation
|
LEF1 | 0.75 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MAP3K7 | up-regulates
phosphorylation
|
NLK | 0.631 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NLK | down-regulates
phosphorylation
|
NOTCH1 | 0.394 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | FZD3 | up-regulates
binding
|
NLK | 0.362 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NLK | down-regulates quantity
phosphorylation
|
TCF7L2 | 0.763 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NLK | form complex 
binding
|
SETDB1/NLK/CHD7 | 0.419 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | NLK | down-regulates
phosphorylation
|
TCF4 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |