Summary
Name | SHOC2 View Modifications |
Full Name | Leucine-rich repeat protein SHOC-2 |
Synonyms | Protein soc-2 homolog, Protein sur-8 homolog | KIAA0862 |
Primary ID | Q9UQ13 |
Links | - - |
Type | protein |
Relations | 6 |
Pathways | Noonan syndrome |
Function | Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes. |
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Modifications Tables
Relations
Regulator | Mechanism | target | score ℹ | |
---|---|---|---|---|
+ | PRKCD | down-regulates quantity by destabilization phosphorylation | SHOC2 | 0.2 |
Publications: | 2 | |||
+ | PRKCA | down-regulates quantity by destabilization phosphorylation | SHOC2 | 0.2 |
Publications: | 2 | |||
+ | SHOC2 | up-regulates binding | MRAS | 0.682 |
Publications: | 1 | Organism: | Homo Sapiens | |
Pathways: | Noonan syndrome | |||
+ | SHOC2 | up-regulates activity binding | PPP1CA | 0.57 |
Publications: | 1 | Organism: | Homo Sapiens | |
Pathways: | Noonan syndrome |