4.0
Summary
| Name |  SHOC2View Modifications |
| Full Name | Leucine-rich repeat protein SHOC-2 |
| Synonyms | Protein soc-2 homolog, Protein sur-8 homolog | KIAA0862 |
| Primary ID | Q9UQ13 |
| Links |  -  -  |
| Type | protein |
| Relations | 9 |
| Pathways | Noonan syndrome |
| Function | Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PRKCD | down-regulates quantity by destabilization 
phosphorylation
|
SHOC2 | 0.2 |
| Publications: | 2 | |||
| + | PRKCA | down-regulates quantity by destabilization
phosphorylation
|
SHOC2 | 0.2 |
| Publications: | 2 | |||
| + | MAPK3 | down-regulates quantity by destabilization
phosphorylation
|
SHOC2 | 0.336 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MAPK1 | down-regulates quantity by destabilization
phosphorylation
|
SHOC2 | 0.324 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SHOC2 | up-regulates activity 
binding
|
PPP1CA | 0.593 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Noonan syndrome | |||
| + | SCF-FBW7 | down-regulates quantity by destabilization
polyubiquitination
|
SHOC2 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SHOC2 | up-regulates
binding
|
MRAS | 0.691 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Noonan syndrome | |||