4.0
Summary
| Name |  POLHView Modifications |
| Full Name | DNA polymerase eta |
| Synonyms | RAD30 homolog A, Xeroderma pigmentosum variant type protein | RAD30, RAD30A, XPV |
| Primary ID | Q9Y253 |
| Links |  -  -  |
| Type | protein |
| Relations | 8 |
| Pathways | DNA repair in cancer |
| Function | DNA polymerase specifically involved in the DNA repair by translesion synthesis (TLS) (PubMed:10385124, PubMed:11743006, PubMed:24449906, PubMed:24553286, PubMed:16357261). Due to low processivity on both damaged and normal DNA, cooperates with the heterotetrameric (REV3L, REV7, POLD2 and POLD3) POLZ complex for complete bypass of DNA lesions. Inserts one or 2 nucleotide(s) opposite the lesion, the primer is further extended by the tetrameric POLZ complex. In the case of 1,2-intrastrand d(GpG)-cisplatin cross-link, inserts dCTP opposite the 3' guanine (PubMed:24449906). Particularly important for the repair of UV-induced pyrimidine dimers (PubMed:10385124, PubMed:11743006). Although inserts the correct base, may cause base transitions and transversions depending upon the context. May play a role in hypermutation at immunoglobulin genes (PubMed:11376341, PubMed:14734526). Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have any lyase activity, preventing the release of the 5'-deoxyribose phosphate (5'-dRP) residue. This covalent trapping of the enzyme by the 5'-dRP residue inhibits its DNA synthetic activity during base excision repair, thereby avoiding high incidence of mutagenesis (PubMed:14630940). Targets POLI to replication foci (PubMed:12606586). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | RCHY1 | down-regulates activity 
monoubiquitination
|
POLH | 0.582 |
| Publications: | 4 | Organism: | Homo Sapiens | |
| + | ATR | up-regulates 
phosphorylation
|
POLH | 0.414 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | DNA repair in cancer | |||
| + | POLH | up-regulates 
|
DNA_repair | 0.7 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | DNA repair in cancer | |||
| + | BRCA2 | up-regulates
binding
|
POLH | 0.554 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | DNA repair in cancer | |||
| + | PALB2 | up-regulates
binding
|
POLH | 0.539 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | DNA repair in cancer | |||