Summary

Name RNF11
Full Name RING finger protein 11
Synonyms RNF11_HUMAN
Primary ID Q9Y3C5
Links - -
Type protein
Relations 6
Pathways NF-KB Canonical
Function Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates quantity img/direct_inhibition.png phosphorylation RNF11 0.472
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png phosphorylation RNF11 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding SMURF2 0.562
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png ubiquitination RNF11 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding ITCH 0.575
Publications: 1 Organism: Homo Sapiens
Pathways:IL1 Signaling , NF-KB Canonical
+ down-regulates quantity by destabilization img/direct_inhibition.png binding STAMBP 0.553
Publications: 1 Organism: Homo Sapiens