Summary

Name ATG4B
Full Name Cysteine protease ATG4B
Synonyms AUT-like 1 cysteine endopeptidase, Autophagin-1, Autophagy-related cysteine endopeptidase 1, Autophagy-related protein 4 homolog B, hAPG4B | APG4B, AUTL1, KIAA0943
Primary ID Q9Y4P1
Links - -
Type protein
Relations 9
Pathways Autophagy
Function Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3, GABARAPL1, GABARAPL2 and GABARAP, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation ATG4B
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ATG4B
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ATG4B
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ATG4B
Publications: 1
+ up-regulates activity img/direct-activation.png cleavage GABARAP 0.856
Publications: 1 Organism: In Vitro
Pathways:Autophagy
+ up-regulates activity img/direct-activation.png cleavage GABARAPL2 0.838
Publications: 1 Organism: In Vitro
Pathways:Autophagy
+ down-regulates activity img/indirect_inhibition.png ATP synthase
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png cleavage MAP1LC3B 0.795
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png cleavage MAP1LC3C 0.748
Publications: 1 Organism: Homo Sapiens
Pathways:Autophagy