Summary

Name UCHL5
Full Name Ubiquitin carboxyl-terminal hydrolase isozyme L5
Synonyms UCH-L5, Ubiquitin C-terminal hydrolase UCH37, Ubiquitin thioesterase L5 | UCH37
Primary ID Q9Y5K5
Links - -
Type protein
Relations 5
Function Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1.

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Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png deubiquitination SMAD2 0.35
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding SMAD7 0.43
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png stabilization TGFBR1 0.42
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png deubiquitination SMAD3 0.32
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png deubiquitination SMAD2 0.35
Publications: 1 Organism: Homo Sapiens