| + |
Exon junction complex | up-regulates activity 
binding
|
Upf-EJC |
0.858 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265244 |
|
|
in vitro |
|
| pmid |
sentence |
| 18066079 |
Nonsense-mediated mRNA decay (NMD) eliminates mRNAs containing a premature translation termination codon through the recruitment of the conserved NMD factors UPF1, UPF2 and UPF3. In humans, a dynamic assembly pathway allows UPF1 to join UPF2 and UPF3 recruited to the mRNA by the exon-junction complex (EJC). |
|
| Publications: |
1 |
Organism: |
In Vitro |
| Pathways: | mRNA maturation, mRNA maturation |
| + |
UPF1 | form complex 
binding
|
Upf-EJC |
0.968 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265237 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 17803942 |
The three Up-frameshift (Upf) proteins, Upf1, Upf2, and Upf3 that together form the Upf complex, constitute the conserved core of NMD from yeast to humans. hUpf3b Forms Multiple Contacts with the EJC and Depends on hUpf2 for Complex Formation with hUpf1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Upf-EJC | up-regulates
|
Nonsense-mediated mRNA decay |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265239 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 17803942 |
The three Up-frameshift (Upf) proteins, Upf1, Upf2, and Upf3 that together form the Upf complex, constitute the conserved core of NMD from yeast to humans. hUpf3b Forms Multiple Contacts with the EJC and Depends on hUpf2 for Complex Formation with hUpf1. the hUpf complex communicates with the EJC and triggers NMD in the cytoplasm. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | mRNA maturation, mRNA maturation |
| + |
UPF3B | form complex
binding
|
Upf-EJC |
0.961 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265236 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 17803942 |
The three Up-frameshift (Upf) proteins, Upf1, Upf2, and Upf3 that together form the Upf complex, constitute the conserved core of NMD from yeast to humans. hUpf3b Forms Multiple Contacts with the EJC and Depends on hUpf2 for Complex Formation with hUpf1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
UPF2 | form complex
binding
|
Upf-EJC |
0.972 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265238 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 17803942 |
The three Up-frameshift (Upf) proteins, Upf1, Upf2, and Upf3 that together form the Upf complex, constitute the conserved core of NMD from yeast to humans. hUpf3b Forms Multiple Contacts with the EJC and Depends on hUpf2 for Complex Formation with hUpf1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
Upf-EJC