| + |
Exon junction complex | up-regulates activity 
relocalization
|
messenger RNA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268315 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11532962 |
The exon–exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | mRNA maturation, mRNA maturation |
| + |
EIF4A3 | form complex 
binding
|
Exon junction complex |
0.948 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265240 |
|
|
in vitro |
|
| pmid |
sentence |
| 16923391 |
The EJC is deposited onto mRNA during splicing and is transported to the cytoplasm where it influences translation, surveillance, and localization of the spliced mRNA. The complex is formed by the association of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
Exon junction complex | up-regulates activity
binding
|
Upf-EJC |
0.863 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265244 |
|
|
in vitro |
|
| pmid |
sentence |
| 18066079 |
Nonsense-mediated mRNA decay (NMD) eliminates mRNAs containing a premature translation termination codon through the recruitment of the conserved NMD factors UPF1, UPF2 and UPF3. In humans, a dynamic assembly pathway allows UPF1 to join UPF2 and UPF3 recruited to the mRNA by the exon-junction complex (EJC). |
|
| Publications: |
1 |
Organism: |
In Vitro |
| Pathways: | mRNA maturation, mRNA maturation |
| + |
Exon junction complex | up-regulates 
|
mRNA_nuclear_export |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268313 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11532962 |
The exon–exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CASC3 | form complex
binding
|
Exon junction complex |
0.925 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265241 |
|
|
in vitro |
|
| pmid |
sentence |
| 16923391 |
The EJC is deposited onto mRNA during splicing and is transported to the cytoplasm where it influences translation, surveillance, and localization of the spliced mRNA. The complex is formed by the association of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
MAGOH | form complex
binding
|
Exon junction complex |
0.952 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265243 |
|
|
in vitro |
|
| pmid |
sentence |
| 16923391 |
The EJC is deposited onto mRNA during splicing and is transported to the cytoplasm where it influences translation, surveillance, and localization of the spliced mRNA. The complex is formed by the association of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
RBM8A | form complex
binding
|
Exon junction complex |
0.919 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265242 |
|
|
in vitro |
|
| pmid |
sentence |
| 16923391 |
The EJC is deposited onto mRNA during splicing and is transported to the cytoplasm where it influences translation, surveillance, and localization of the spliced mRNA. The complex is formed by the association of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. |
|
| Publications: |
1 |
Organism: |
In Vitro |
4.0
Exon junction complex
CPX-1941