| + |
P300/PCAF | up-regulates activity 
acetylation
|
SMAD2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217607 |
Lys19 |
VKRLLGWkKSAGGSG |
Homo sapiens |
|
| pmid |
sentence |
| 17074756 |
Acetylation of the short isoform of Smad2 improves its DNA binding activity in vitro and enhances its association with target promoters in vivo, thereby augmenting its transcriptional activity. Smad2(FL) and Smad2(_E3) were also acetylated by P/CAF in vivo and the acetylation of both proteins was lost following mutation of Lys19 (Fig. 2D), suggesting that Lys19 in Smad2 is also targeted by P/CAF. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CREBBP | form complex 
binding
|
P300/PCAF |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-170262 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21131905 |
Histone acetyltransferases (hats) gcn5 and pcaf (gcn5/pcaf) and cbp and p300 (cbp/p300) are transcription co-activators. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
P300/PCAF | up-regulates
binding
|
SMAD2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217230 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 15009097 |
Gcn5 functions like pcaf, in that it binds to tgf-beta-specific r-smads, and enhances transcriptional activity induced by tgf-beta. In addition, gcn5, but not pcaf, interacts with r-smads for bone morphogenetic protein (bmp) signalling pathways, and enhances bmp-induced transcriptional activity, suggesting that gcn5 and pcaf have distinct physiological functions in vivo. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
P300/PCAF | up-regulates
binding
|
SMAD3 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217233 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 15009097 |
Gcn5 functions like pcaf, in that it binds to tgf-beta-specific r-smads, and enhances transcriptional activity induced by tgf-beta. In addition, gcn5, but not pcaf, interacts with r-smads for bone morphogenetic protein (bmp) signalling pathways, and enhances bmp-induced transcriptional activity, suggesting that gcn5 and pcaf have distinct physiological functions in vivo. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AKT1 | up-regulates
phosphorylation
|
P300/PCAF |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217670 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17964260 |
Akt1 and 2 promote the association of myod with p300 and pcaf acetyltransferases, via direct phosphorylation of p300. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle |
| Pathways: | P38 Signaling and Myogenesis |
| + |
AKT2 | up-regulates
phosphorylation
|
P300/PCAF |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217673 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17964260 |
Akt1 and 2 promote the association of myod with p300 and pcaf acetyltransferases, via direct phosphorylation of p300. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle |
| Pathways: | P38 Signaling and Myogenesis |
| + |
KAT2B | form complex
binding
|
P300/PCAF |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-170276 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21131905 |
Histone acetyltransferases (hats) gcn5 and pcaf (gcn5/pcaf) and cbp and p300 (cbp/p300) are transcription co-activators. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EP300 | form complex
binding
|
P300/PCAF |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-170273 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21131905 |
Histone acetyltransferases (hats) gcn5 and pcaf (gcn5/pcaf) and cbp and p300 (cbp/p300) are transcription co-activators. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
P300/PCAF