Summary

Name KAT2B
Full Name Histone acetyltransferase KAT2B
Synonyms Histone acetyltransferase PCAF, Histone acetylase PCAF, Lysine acetyltransferase 2B, P300/CBP-associated factor, P/CAF | PCAF
Primary ID Q92831
Links - -
Type protein
Relations 10
Function Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Also acetylates non-histone proteins, such as ACLY. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png acetylation SMAD2 0.17
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MEF2C 0.18
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding P300/PCAF
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png acetylation NOTCH1
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png acetylation NOTCH
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png acetylation, binding MYOD1 0.39
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates img/direct-activation.png binding SMAD3 0.24
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding KAT2B 0.32
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle