| + |
KAT2B | down-regulates activity 
acetylation
|
H3C1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269611 |
Lys10 |
RTKQTARkSTGGKAP |
Homo sapiens |
|
| pmid |
sentence |
| 34811519 |
The HAT module within the SAGA and ADA complexes acetylates histone H3, mainly on residues K9 and K14. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269619 |
Lys15 |
ARKSTGGkAPRKQLA |
Homo sapiens |
|
| pmid |
sentence |
| 34811519 |
The HAT module within the SAGA and ADA complexes acetylates histone H3, mainly on residues K9 and K14. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
KAT2B | down-regulates activity
acetylation
|
H3-4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269613 |
Lys10 |
RTKQTARkSTGGKAP |
Homo sapiens |
|
| pmid |
sentence |
| 34811519 |
The HAT module within the SAGA and ADA complexes acetylates histone H3, mainly on residues K9 and K14. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269621 |
Lys15 |
ARKSTGGkAPRKQLA |
Homo sapiens |
|
| pmid |
sentence |
| 34811519 |
The HAT module within the SAGA and ADA complexes acetylates histone H3, mainly on residues K9 and K14. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
KAT2B | down-regulates activity
acetylation
|
H3-2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269616 |
Lys10 |
RTKQTARkSTGGKAP |
Homo sapiens |
|
| pmid |
sentence |
| 34811519 |
The HAT module within the SAGA and ADA complexes acetylates histone H3, mainly on residues K9 and K14. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269624 |
Lys15 |
ARKSTGGkAPRKQLA |
Homo sapiens |
|
| pmid |
sentence |
| 34811519 |
The HAT module within the SAGA and ADA complexes acetylates histone H3, mainly on residues K9 and K14. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
KAT2B | down-regulates activity
acetylation
|
H3Y1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269614 |
Lys10 |
RTKQTARkATAWQAP |
Homo sapiens |
|
| pmid |
sentence |
| 34811519 |
The HAT module within the SAGA and ADA complexes acetylates histone H3, mainly on residues K9 and K14. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KAT2B | down-regulates activity
acetylation
|
H3-5 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269617 |
Lys10 |
RTKQTARkSTGGKAP |
Homo sapiens |
|
| pmid |
sentence |
| 34811519 |
The HAT module within the SAGA and ADA complexes acetylates histone H3, mainly on residues K9 and K14. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269625 |
Lys15 |
ARKSTGGkAPRKQLA |
Homo sapiens |
|
| pmid |
sentence |
| 34811519 |
The HAT module within the SAGA and ADA complexes acetylates histone H3, mainly on residues K9 and K14. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
KAT2B | down-regulates activity
acetylation
|
H3-3A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269612 |
Lys10 |
RTKQTARkSTGGKAP |
Homo sapiens |
|
| pmid |
sentence |
| 34811519 |
The HAT module within the SAGA and ADA complexes acetylates histone H3, mainly on residues K9 and K14. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269620 |
Lys15 |
ARKSTGGkAPRKQLA |
Homo sapiens |
|
| pmid |
sentence |
| 34811519 |
The HAT module within the SAGA and ADA complexes acetylates histone H3, mainly on residues K9 and K14. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
KAT2B | down-regulates activity
acetylation
|
H3C15 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269618 |
Lys10 |
RTKQTARkSTGGKAP |
Homo sapiens |
|
| pmid |
sentence |
| 34811519 |
The HAT module within the SAGA and ADA complexes acetylates histone H3, mainly on residues K9 and K14. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269626 |
Lys15 |
ARKSTGGkAPRKQLA |
Homo sapiens |
|
| pmid |
sentence |
| 34811519 |
The HAT module within the SAGA and ADA complexes acetylates histone H3, mainly on residues K9 and K14. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
KAT2B | down-regulates activity
acetylation
|
H3Y2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269615 |
Lys10 |
RTKQTARkATAWQAP |
Homo sapiens |
|
| pmid |
sentence |
| 34811519 |
The HAT module within the SAGA and ADA complexes acetylates histone H3, mainly on residues K9 and K14. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KAT2B | up-regulates 
acetylation
|
SMAD2 |
0.554 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-150273 |
Lys19 |
VKRLLGWkKSAGGSG |
Homo sapiens |
|
| pmid |
sentence |
| 17074756 |
We demonstrate that both smad2 and smad3 are acetylated by the coactivators p300 and cbp in a tgfbeta-dependent manner. Smad2 is also acetylated by p/caf. The acetylation of smad2 was significantly higher than that of smad3. Lys(19) in the mh1 domain was identified as the major acetylated residue in both the long and short isoform of smad2.....acetylation of the short isoform of smad2 improves its dna binding activity in vitro and enhances its association with target promoters in vivo, thereby augmenting its transcriptional activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KAT2B | up-regulates
binding
|
MEF2C |
0.551 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-84032 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11062529 |
The cofactors grip-1, cbp/p300 and pcaf have hat activity and function as co-activators for mef-2c during myogenesis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KAT2B | up-regulates
acetylation
|
NOTCH1 |
0.58 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199024 |
|
|
Homo sapiens |
T-lymphocyte, Leukemia Cell |
| pmid |
sentence |
| 23029358 |
In earlier studies, we demonstrated that maml1 enhanced p300 acetyltransferase activity, which increased the acetylation of notch by p300.Acetylation controls notch stability and function in t-cell leukemia. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-177749 |
|
|
Homo sapiens |
T-lymphocyte, Leukemia Cell |
| pmid |
sentence |
| 22120716 |
In earlier studies, we demonstrated that maml1 enhanced p300 acetyltransferase activity, which increased the acetylation of notch by p300.Acetylation controls notch stability and function in t-cell leukemia. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
NR3C1 | up-regulates activity
relocalization
|
KAT2B |
0.526 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269233 |
|
|
|
|
| pmid |
sentence |
| 32917954 |
NR3C1 impaired GLI1 function by dynamically modulating the recruitment of PCAF acetyltransferase |
|
| Publications: |
1 |
| + |
KAT2B | up-regulates
binding
|
SMAD3 |
0.661 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-83607 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11058129 |
P/caf was found to interact directly with smad3 in vitro. Moreover, smad2 and smad3 interacted with p/caf upon tgf-beta type i receptor activation in cultured mammalian cells. these results demonstrate the co-activator function of p/caf for smad2 and smad3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SIRT2 | down-regulates
binding
|
KAT2B |
0.551 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-104248 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12887892 |
Sir2 forms a complex with the acetyltransferase pcaf and myod and, when overexpressed, retards muscle differentiation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle |
| + |
KAT2B | up-regulates
acetylation
|
NOTCH |
0.58 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254311 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22120716 |
In earlier studies, we demonstrated that maml1 enhanced p300 acetyltransferase activity, which increased the acetylation of notch by p300.Acetylation controls notch stability and function in t-cell leukemia. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KAT2B | form complex 
binding
|
P300/PCAF |
0.769 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-170276 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21131905 |
Histone acetyltransferases (hats) gcn5 and pcaf (gcn5/pcaf) and cbp and p300 (cbp/p300) are transcription co-activators. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KAT2B | up-regulates
acetylation, binding
|
MYOD1 |
0.628 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-81056 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10944526 |
Our results provide direct evidence that myod acetylation functionally activates the protein and show that both pcaf and cbp/p300 are candidate enzymes for myod acetylation in vivo |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-81059 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10944526 |
Our results provide direct evidence that myod acetylation functionally activates the protein and show that both pcaf and cbp/p300 are candidate enzymes for myod acetylation in vivo |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle |
| + |
KAT2B | down-regulates activity
acetylation
|
Histone H3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269610 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34811519 |
The HAT module within the SAGA and ADA complexes acetylates histone H3, mainly on residues K9 and K14. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KAT2B | down-regulates activity
acetylation
|
GLI1 |
0.484 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269270 |
|
|
|
|
| pmid |
sentence |
| 32917954 |
NR3C1 impaired GLI1 function by dynamically modulating the recruitment of PCAF acetyltransferase |
|
| Publications: |
1 |
| + |
KAT2B | form complex
binding
|
SAGA complex |
0.66 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269592 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34811519 |
Here we present the cryogenic-electron microscopy (cryo-EM) structure of human SAGA (hSAGA)|Human SAGA is a 20-subunit, 1.4-MDa complex with five functional modules (Fig. (Fig.1a):1a): a scaffolding core that includes TBP-associated factors (TAFs); a TRRAP (Transformation/Transcription domain Associated Protein) containing a phosphoinositide-3-kinase (PI3K)-related pseudoprotein kinase (ΨPIKK); a histone acetyltransferase (HAT); a deubiquitinase (DUB) and a metazoan-specific splicing (SPL) module |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
KAT2B
- 
- 