3.0
Macrophage: IL6
Pathway ID: SIGNOR-MacroIL6
Description: IL6-type cytokines play an important role in the regulation of complex cellular processes such as gene activation, proliferation and differentiation. IL6-type cytokines exert their action via the signal transducer gp130 that associates with IL6R in a cooperative manner to form a complex capable of activating the JAK/STAT pathway. This signaling cascade plays an important role in immune regulation, hematopoiesis, inflammation and oncogenesis.
Curated by: Alessandro Palma
Description: IL6-type cytokines play an important role in the regulation of complex cellular processes such as gene activation, proliferation and differentiation. IL6-type cytokines exert their action via the signal transducer gp130 that associates with IL6R in a cooperative manner to form a complex capable of activating the JAK/STAT pathway. This signaling cascade plays an important role in immune regulation, hematopoiesis, inflammation and oncogenesis.
Curated by: Alessandro Palma
