3.0
Macrophage: Metabolic switch
Pathway ID: SIGNOR-MacroMS
Description: Macrophage polarization strongly depends on their metabolism of arginine. M1 macrophages express the enzyme nitric oxide synthase, which metabolizes arginine to nitric oxide and citrulline. M2 macrophages express the enzyme arginase, which limits the arginine availability for nitric oxide synthase and catalizes the production of proline and polyamines (spermine, spermidine and putrescine).
Curated by: Alessandro Palma
Description: Macrophage polarization strongly depends on their metabolism of arginine. M1 macrophages express the enzyme nitric oxide synthase, which metabolizes arginine to nitric oxide and citrulline. M2 macrophages express the enzyme arginase, which limits the arginine availability for nitric oxide synthase and catalizes the production of proline and polyamines (spermine, spermidine and putrescine).
Curated by: Alessandro Palma
8 Seed Entities
Organism: 
|
Name | Primary ID |
|---|---|
| STAT6 | P42226 |
| L-ornithine | CHEBI:15729 |
| M1_polarization | SIGNOR-PH54 |
| L-arginine | CHEBI:16467 |
| NOS2 | P35228 |
| M2_polarization | SIGNOR-PH55 |
| nitric oxide | CHEBI:16480 |
| ARG1 | P05089 |