Summary

Name ARG1
Full Name Arginase-1
Synonyms Liver-type arginase, Type I arginase |
Primary ID P05089
Links - -
Type protein
Relations 4
Pathways Fibroblast: Arginine metabolism and collagen synthesis, Macrophage: Metabolic switch
Function Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys.

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Relations

Regulator Mechanism target score
+ up-regulates img/indirect-activation.png ARG1 0.8
Publications: 1
Tissue: Skeletal Muscle
+ up-regulates quantity img/direct-activation.png chemical modification L-ornithine 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png ARG1 0.418
Publications: 1
Tissue: Skeletal Muscle
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ARG1 0.2
Publications: 1 Organism: Homo Sapiens