+ |
L-arginine | up-regulates
|
ARG1 |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-255555 |
|
|
|
Macrophage |
pmid |
sentence |
25386178 |
In mammalian cells, arginine can be catabolized by four classes of enzymes (Figure (Figure1):1): NOS, arginase, arginine decarboxylase (ADC), and arginine:glycine amidinotransferase (AGAT) |
|
Publications: |
1 |
Tissue: |
Skeletal Muscle |
+ |
ARG1 | up-regulates quantity
chemical modification
|
L-ornithine |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-255545 |
|
|
Homo sapiens |
|
pmid |
sentence |
14617280 |
Arginase generates ornithine, an aminoacid that can be further metabolized to proline via ornithine aminotransferase and to polyamines via ornithine decarboxylase (ODC) |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
STAT6 | up-regulates
|
ARG1 |
0.418 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-255557 |
|
|
|
Macrophage |
pmid |
sentence |
25386178 |
Cytokines like IL-4 or IL-13 lead to STAT6 phosphorylation with consecutive arginase expression and varying further aspects of M2 polarization (mannose receptor, Ym1, Fizz1) |
|
Publications: |
1 |
Tissue: |
Skeletal Muscle |
+ |
AR | up-regulates quantity by expression
transcriptional regulation
|
ARG1 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-253738 |
|
|
Homo sapiens |
LNCaP Cell |
pmid |
sentence |
20711410 |
The regulation of arginase expression following androgen stimulation was dependent on the androgen receptor (AR), as a siRNA treatment targeting the AR inhibited both ARG1 and ARG2 overexpression. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |