3.0
Myofiber: Glucocorticoid-induced atrophy
Pathway ID: SIGNOR-MyoATRView in NDEx
Description: FOXO and Glucocorticoid receptor regulate the expression of two genes principally involved in the majority of atrophies. FOXO family members are involved in the activation of atrogenes such as Atrogin-1 and MuRF-1. Like FOXOs, Dexamethasone interacts and activates the glucocorticoid receptor that subsequentially leads to Atrogin-1 and MuRF-1 gene activation. Atrogin-1 and MuRF-1 induce atrophy by promoting protein degradation phenomena.
Curated by: Alessio Reggio
Description: FOXO and Glucocorticoid receptor regulate the expression of two genes principally involved in the majority of atrophies. FOXO family members are involved in the activation of atrogenes such as Atrogin-1 and MuRF-1. Like FOXOs, Dexamethasone interacts and activates the glucocorticoid receptor that subsequentially leads to Atrogin-1 and MuRF-1 gene activation. Atrogin-1 and MuRF-1 induce atrophy by promoting protein degradation phenomena.
Curated by: Alessio Reggio
6 Seed Entities
Organism: 
|
Name | Primary ID |
|---|---|
| Muscle_atrophy | SIGNOR-PH40 |
| FBXO32 | Q969P5 |
| NR3C1 | P04150 |
| FOXO3 | O43524 |
| TRIM63 | Q969Q1 |
| dexamethasone | CHEBI:41879 |