| + |
FOXO1 | up-regulates quantity by expression 
transcriptional regulation
|
FBXO32 |
0.44 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236540 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21798082 |
Foxo factors are required for the transcriptional regulation of the ubiquitin ligases atrogin-1, also called muscle atrophy f-box (mafbx) and muscle ring finger 1 (murf1), leading to the ubiquitylation of myosin and other muscle proteins, and their degradation via the proteasome. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252069 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 15109499 |
The activity of the PI3K/AKT pathway decreases, leading to activation of Foxo transcription factors and atrogin-1 induction. IGF-1 treatment or AKT overexpression inhibits Foxo and atrogin-1 expression. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, Mus Musculus |
| Pathways: | IGF and Myogenesis |
| + |
FBXO32 | up-regulates
|
Protein_degradation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255342 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 11717410 |
Atrogin-1 is one of the few examples of an F-box protein or Ub-protein ligase (E3) expressed in a tissue-specific manner and appears to be a critical component in the enhanced proteolysis leading to muscle atrophy in diverse diseases |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255341 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 20871233 |
Atrogin-1, but not MuRF-1, was induced at both the gene and protein level as ApcMin/+ mice aged from 3 to 6 months of age, going from a pre-cachectic to a cachectic state. Atrogin-1 mRNA and protein levels were also elevated in ApcMin/+ mice when we over-expressed IL-6 in the circulation. |
|
| Publications: |
2 |
Organism: |
Mus Musculus |
| + |
FOXO | up-regulates quantity by expression 
transcriptional regulation
|
FBXO32 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254991 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 18612045 |
These findings present new insights into the role of the GR and FOXO family of transcription factors in the transcriptional regulation of the MuRF1 gene, a direct target of the GR in skeletal muscle. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252929 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 15109499 |
Constitutively active Foxo3 acts on the atrogin-1 promoter to cause atrogin-1 transcription and dramatic atrophy of myotubes and muscle fibers |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252926 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 15109499 |
The activity of the PI3K/AKT pathway decreases, leading to activation of Foxo transcription factors and atrogin-1 induction. IGF-1 treatment or AKT overexpression inhibits Foxo and atrogin-1 expression. |
|
| Publications: |
3 |
Organism: |
Mus Musculus |
| + |
FBXO32 | down-regulates quantity by destabilization 
ubiquitination, binding
|
MYOD1 |
0.577 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-184861 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19319192 |
Here we present evidence that mafbx targets myod for degradation in several models of skeletal muscle atrophy. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271802 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 19319192 |
We previously showed that the level of MAFbx protein increased in skeletal muscle during aging and/or food deprivation. Immunoprecipitation of the SCFMAFbx complexes from mouse atrophic muscles exhibited ubiquitination activity by using MyoD as substrate. Food deprivation and oxidative stress–induced atrophy increase polyubiquitination by the SCFMAFbx pathway and degradation of MyoD by the proteasome |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, Mus Musculus |
| Tissue: |
Skeletal Muscle |
| Pathways: | IGF and Myogenesis |
| + |
FBXO32 | up-regulates activity
|
Muscle_atrophy |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254994 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 25549588 |
Muscle-specific ubiq- uitin ligases, muscle-specific RING-finger 1 (MURF1; also known as TRIM63)12 and atrogin 1 (also known as MAFBX)8, are markedly induced in almost all types of atrophy. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
FOXO3 | up-regulates quantity by expression
transcriptional regulation
|
FBXO32 |
0.451 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235715 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21798082 |
Foxo factors are required for the transcriptional regulation of the ubiquitin ligases atrogin-1, also called muscle atrophy f-box (mafbx) and muscle ring finger 1 (murf1), leading to the ubiquitylation of myosin and other muscle proteins, and their degradation via the proteasome. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252070 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 15109499 |
Constitutively active Foxo3 acts on the atrogin-1 promoter to cause atrogin-1 transcription and dramatic atrophy of myotubes and muscle fibers |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-232174 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15109499 |
Moreover, constitutively active Foxo3 acts on the atrogin-1 promoter to cause atrogin-1 transcription and dramatic atrophy of myotubes and muscle fibers. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens, Mus Musculus |
| Tissue: |
Muscle |
| Pathways: | IGF and Myogenesis |
| + |
FBXO32 | up-regulates activity
binding
|
Cullin 1-RBX1-Skp1 |
0.58 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271803 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 19319192 |
We previously showed that the level of MAFbx protein increased in skeletal muscle during aging and/or food deprivation. Immunoprecipitation of the SCFMAFbx complexes from mouse atrophic muscles exhibited ubiquitination activity by using MyoD as substrate. Food deprivation and oxidative stress–induced atrophy increase polyubiquitination by the SCFMAFbx pathway and degradation of MyoD by the proteasome |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
FBXO32 | up-regulates
|
Muscle_atrophy |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255344 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 11717410 |
Atrogin-1 is one of the few examples of an F-box protein or Ub-protein ligase (E3) expressed in a tissue-specific manner and appears to be a critical component in the enhanced proteolysis leading to muscle atrophy in diverse diseases |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255343 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 20871233 |
Atrogin-1, but not MuRF-1, was induced at both the gene and protein level as ApcMin/+ mice aged from 3 to 6 months of age, going from a pre-cachectic to a cachectic state. Atrogin-1 mRNA and protein levels were also elevated in ApcMin/+ mice when we over-expressed IL-6 in the circulation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252072 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 25096180 |
Muscle RING finger 1 (MuRF1) and muscle atrophy F-box (MAFbx)/atrogin-1 were identified more than 10 years ago as two muscle-specific E3 ubiquitin ligases that are increased transcriptionally in skeletal muscle under atrophy-inducing conditions, making them excellent markers of muscle atrophy |
|
| Publications: |
3 |
Organism: |
Mus Musculus |
| Tissue: |
Skeletal Muscle |
| + |
FOXO4 | up-regulates quantity by expression
transcriptional regulation
|
FBXO32 |
0.383 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236554 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21798082 |
Foxo factors are required for the transcriptional regulation of the ubiquitin ligases atrogin-1, also called muscle atrophy f-box (mafbx) and muscle ring finger 1 (murf1), leading to the ubiquitylation of myosin and other muscle proteins, and their degradation via the proteasome. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle |
| + |
FOXO | up-regulates quantity by expression
transcriptional regulation
|
FBXO32 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252945 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21798082 |
Foxo factors are required for the transcriptional regulation of the ubiquitin ligases atrogin-1, also called muscle atrophy f-box (mafbx) and muscle ring finger 1 (murf1), leading to the ubiquitylation of myosin and other muscle proteins, and their degradation via the proteasome. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle |
| + |
FOXO6 | up-regulates quantity by expression
transcriptional regulation
|
FBXO32 |
0.282 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236560 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21798082 |
Foxo factors are required for the transcriptional regulation of the ubiquitin ligases atrogin-1, also called muscle atrophy f-box (mafbx) and muscle ring finger 1 (murf1), leading to the ubiquitylation of myosin and other muscle proteins, and their degradation via the proteasome. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle |
| + |
YAP1 | down-regulates 
|
FBXO32 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199069 |
|
|
Homo sapiens |
Myoblast, Satellite Cell |
| pmid |
sentence |
| 23038772 |
The downregulation of fbox32 expression by high yap activity in activated satellite cells may contribute to sustaining high levels of myod in activated satellite cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle |
| + |
MYOG | down-regulates activity
binding
|
FBXO32 |
0.527 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-237854 |
|
|
Chlorocebus aethiops |
|
| pmid |
sentence |
| 19631210 |
Myogenin had a MAFbx-recognition motif and interacted with MAFbx. MAFbx activated polyubiquitination of myogenin. The results of this study suggest that MAFbx functions as an F-box protein for ubiquitination of myogenin. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| Pathways: | IGF and Myogenesis |
| + |
STAT3 | up-regulates quantity by expression
transcriptional regulation
|
FBXO32 |
0.286 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255331 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22669242 |
Thus we infected C2C12 myofibers with a recombinant adenovirus expressing a mutant, constitutively activated STAT3 (cSTAT3) known to possess increased DNA binding/transcriptional activity. Consistent with wasting, atrogin-1 expression was also markedly increased (Fig. 3A). Thus STAT3 activation is by itself sufficient to induce muscle fiber wasting in cell culture. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
3.0
FBXO32
- 
- 