Summary

Name FBXO32
Full Name F-box only protein 32
Synonyms Atrogin-1, Muscle atrophy F-box protein, MAFbx
Primary ID Q969P5
Links - -
Type protein
Relations 23
Pathways Myofiber: BMP, Myofiber: Glucocorticoid-induced atrophy, Myofiber: IL6 and atrophy, Myostatin, Satellite: IGF1R
Function Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1.

Viewer

Relations

Regulator Mechanism target score
+ down-regulates quantity by destabilization img/direct_inhibition.png binding, ubiquitination MYOD1 0.582
Publications: 2 Organism: Mus Musculus, Homo Sapiens
Tissue: Skeletal Muscle
Pathways:IGF and Myogenesis
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FBXO32 0.387
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates activity img/direct-activation.png binding Cullin 1-RBX1-Skp1 0.576
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation FBXO32 0.2
Publications: 3 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FBXO32 0.288
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FBXO32 0.445
Publications: 2 Organism: Mus Musculus, Homo Sapiens
Pathways:IGF and Myogenesis
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FBXO32 0.457
Publications: 3 Organism: Homo Sapiens, Mus Musculus
Tissue: Muscle
Pathways:IGF and Myogenesis
+ down-regulates activity img/direct_inhibition.png binding FBXO32 0.532
Publications: 1 Organism: Chlorocebus Aethiops
Pathways:IGF and Myogenesis
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FBXO32 0.284
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates img/indirect-activation.png Protein_degradation 0.7
Publications: 2 Organism: Mus Musculus
+ up-regulates activity img/indirect-activation.png Muscle_atrophy 0.7
Publications: 1 Organism: Mus Musculus
+ up-regulates img/indirect-activation.png Muscle_atrophy 0.7
Publications: 3 Organism: Mus Musculus
Tissue: Skeletal Muscle
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FBXO32 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ down-regulates img/indirect_inhibition.png FBXO32 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle