| + |
SLC9A7 | down-regulates quantity 
relocalization
|
hydron |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265597 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 31507243 |
Na+/H+ exchangers play pivotal roles in the control of cell and tissue pH by mediating the electroneutral exchange of Na+ and H+ across cellular membranes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SLC9A2 | down-regulates quantity
relocalization
|
hydron |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265592 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 31507243 |
Na+/H+ exchangers play pivotal roles in the control of cell and tissue pH by mediating the electroneutral exchange of Na+ and H+ across cellular membranes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SLC9A3 | down-regulates quantity
relocalization
|
hydron |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265593 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 31507243 |
Na+/H+ exchangers play pivotal roles in the control of cell and tissue pH by mediating the electroneutral exchange of Na+ and H+ across cellular membranes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SLC9A5 | down-regulates quantity
relocalization
|
hydron |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265595 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 31507243 |
Na+/H+ exchangers play pivotal roles in the control of cell and tissue pH by mediating the electroneutral exchange of Na+ and H+ across cellular membranes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SLC9A1 | down-regulates quantity
relocalization
|
hydron |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265591 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 31507243 |
Na+/H+ exchangers play pivotal roles in the control of cell and tissue pH by mediating the electroneutral exchange of Na+ and H+ across cellular membranes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NADH-ubiquinone oxidoreductase-Mitochondrial respiratory chain complex I | up-regulates quantity 
relocalization
|
hydron |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280280 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12231006 |
The energy-transducing NADH: quinone (Q) oxidoreductase (complex I) is the largest and most complicated enzyme complex in the oxidative phosphorylation system. Complex I is a redox pump that uses the redox energy to translocate H(+) (or Na(+)) ions across the membrane, resulting in a significant contribution to energy production. Complex I is located at an entry point of the electron transport chain and initiates electron transfer by oxidizing NADH and the electrons are transferred to a lipid-soluble electron carrier quinone (coenzyme Q) as an electron acceptor. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CoQ-cytochrome c reductase-Mitochondrial respiratory chain complex III | up-regulates quantity
relocalization
|
hydron |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280289 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14977419 |
The bc1 complexes are intrinsic membrane proteins that catalyze the oxidation of ubihydroquinone and the reduction of cytochrome c in mitochondrial respiratory chains and bacterial photosynthetic and respiratory chains. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Cytochrome c oxidase-Mitochondrial respiratory chain complex IV | up-regulates quantity
relocalization
|
hydron |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280293 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10563795 |
Cytochrome c oxidase catalyzes the reduction of molecular oxygen to water, a process in which four electrons, four protons, and one molecule of oxygen are consumed. The reaction is coupled to the pumping of four additional protons across the membrane. According to the currently accepted concept, the pumping of all four protons occurs after the binding of oxygen to the reduced enzyme and is exclusively coupled to the last two electron transfer steps. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
hydron | up-regulates activity
chemical modification
|
ATP synthase |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280303 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31115493 |
The mammalian mitochondrial electron transport chain (ETC) includes complexes I‑IV, as well as the electron transporters ubiquinone and cytochrome c. There are two electron transport pathways in the ETC: Complex I/III/IV, with NADH as the substrate and complex II/III/IV, with succinic acid as the substrate. The electron flow is coupled with the generation of a proton gradient across the inner membrane and the energy accumulated in the proton gradient is used by complex V (ATP synthase) to produce ATP. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SLC9A4 | down-regulates quantity
relocalization
|
hydron |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265594 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 31507243 |
Na+/H+ exchangers play pivotal roles in the control of cell and tissue pH by mediating the electroneutral exchange of Na+ and H+ across cellular membranes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SLC9A8 | down-regulates quantity
relocalization
|
hydron |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265598 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 31507243 |
Na+/H+ exchangers play pivotal roles in the control of cell and tissue pH by mediating the electroneutral exchange of Na+ and H+ across cellular membranes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SLC9A9 | down-regulates quantity
relocalization
|
hydron |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265599 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 31507243 |
Na+/H+ exchangers play pivotal roles in the control of cell and tissue pH by mediating the electroneutral exchange of Na+ and H+ across cellular membranes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SLC9A6 | down-regulates quantity
relocalization
|
hydron |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265596 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 31507243 |
Na+/H+ exchangers play pivotal roles in the control of cell and tissue pH by mediating the electroneutral exchange of Na+ and H+ across cellular membranes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
hydron
