| + |
SGK1 | up-regulates activity 
phosphorylation
|
SLC9A1 |
0.305 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280123 |
Ser703 |
MSRARIGsDPLAYEP |
Homo sapiens |
|
| pmid |
sentence |
| 25270604 |
Phosphorylation of NHE1 Ser 703 by SGK1 is essential for the binding of 14-3-3 protein to NHE1 , ] which, in turn, is critical in the activation of this Na + / H + exchanger , ].|These data suggest that endothelial SGK1 activates NHE1 in response to MG treatment. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RPS6KA1 | up-regulates
phosphorylation
|
SLC9A1 |
0.453 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-69171 |
Ser703 |
MSRARIGsDPLAYEP |
Homo sapiens |
|
| pmid |
sentence |
| 10400637 |
The results indicate that p90rsk phosphorylates serine 703 of nhe-1, and this phosphorylation is required for growth factor stimulation of na+/h+ exchange. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RPS6K | up-regulates
phosphorylation
|
SLC9A1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252792 |
Ser703 |
MSRARIGsDPLAYEP |
Homo sapiens |
|
| pmid |
sentence |
| 10400637 |
The results indicate that p90rsk phosphorylates serine 703 of nhe-1, and this phosphorylation is required for growth factor stimulation of na+/h+ exchange. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RPS6KA3 | up-regulates activity
phosphorylation
|
SLC9A1 |
0.416 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280119 |
Ser703 |
MSRARIGsDPLAYEP |
Homo sapiens |
|
| pmid |
sentence |
| 30377223 |
In pressured arteries, RSK2 dependent activation of NHE-1 was associated with increased intracellular Ca 2+ transients, which would be expected to increase MLCK activity, thereby contributing to basal tone and myogenic responses.|Together, these data indicate that Ser 703 in NHE-1 is phosphorylated by RSK2, that RSK2 is associated with NHE-1, and that the time course of NHE-1 phosphorylation in response to intraluminal pressure is fast enough for this phosphorylation event to contribute to myogenic vasoconstriction. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | up-regulates
phosphorylation
|
SLC9A1 |
0.571 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-111039 |
Ser723 |
VITIDPAsPQSPESV |
Homo sapiens |
|
| pmid |
sentence |
| 11604491 |
Trophic factor withdrawal: p38 mitogen-activated protein kinase activates nhe1, which induces intracellular alkalinization. activated p38 mapk directly phosphorylated the c terminus of nhe1 within a 40-amino-acid region. Analysis by mass spectroscopy identified four phosphorylation sites on nhe1, thr 717, ser 722, ser 725, and ser 728. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-180044 |
Ser726 |
IDPASPQsPESVDLV |
Homo sapiens |
|
| pmid |
sentence |
| 18701649 |
Such results suggest that during apoptosis, oxidative stress could activate p38 mapk, phosphorylating nhe1 at s726 and s729. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-111043 |
Ser726 |
IDPASPQsPESVDLV |
Homo sapiens |
|
| pmid |
sentence |
| 11604491 |
Trophic factor withdrawal: p38 mitogen-activated protein kinase activates nhe1, which induces intracellular alkalinization. activated p38 mapk directly phosphorylated the c terminus of nhe1 within a 40-amino-acid region. Analysis by mass spectroscopy identified four phosphorylation sites on nhe1, thr 717, ser 722, ser 725, and ser 728. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-180048 |
Ser729 |
ASPQSPEsVDLVNEE |
Homo sapiens |
|
| pmid |
sentence |
| 18701649 |
Such results suggest that during apoptosis, oxidative stress could activate p38 mapk, phosphorylating nhe1 at s726 and s729. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-111047 |
Ser729 |
ASPQSPEsVDLVNEE |
Homo sapiens |
|
| pmid |
sentence |
| 11604491 |
Trophic factor withdrawal: p38 mitogen-activated protein kinase activates nhe1, which induces intracellular alkalinization. activated p38 mapk directly phosphorylated the c terminus of nhe1 within a 40-amino-acid region. Analysis by mass spectroscopy identified four phosphorylation sites on nhe1, thr 717, ser 722, ser 725, and ser 728. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-111051 |
Thr718 |
KEDLPVItIDPASPQ |
Homo sapiens |
|
| pmid |
sentence |
| 11604491 |
Trophic factor withdrawal: p38 mitogen-activated protein kinase activates nhe1, which induces intracellular alkalinization. activated p38 mapk directly phosphorylated the c terminus of nhe1 within a 40-amino-acid region. Analysis by mass spectroscopy identified four phosphorylation sites on nhe1, thr 717, ser 722, ser 725, and ser 728. |
|
| Publications: |
6 |
Organism: |
Homo Sapiens |
| + |
MAPK1 | up-regulates
phosphorylation
|
SLC9A1 |
0.67 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-151925 |
Ser770 |
MMRSKETsSPGTDDV |
Homo sapiens |
|
| pmid |
sentence |
| 17209041 |
We have demonstrated that the map kinases extracellular signal-regulated kinases 1 and 2 (erk1/2) are implicated in growth factor activation of nhe1. / our results suggest that amino acids ser770 and ser771 mediate erk-dependent activation of the na+/h+ exchanger in vivo. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP3K14 | up-regulates activity
phosphorylation
|
SLC9A1 |
0.305 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279632 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11369779 |
The Nck-interacting kinase (NIK) phosphorylates the Na+-H+ exchanger NHE1 and regulates NHE1 activation by platelet-derived growth factor.|We now show that NIK binds to and divergently activates the plasma membrane Na(+)-H(+) exchanger NHE1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SLC9A1 | down-regulates quantity 
relocalization
|
hydron |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265591 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 31507243 |
Na+/H+ exchangers play pivotal roles in the control of cell and tissue pH by mediating the electroneutral exchange of Na+ and H+ across cellular membranes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ROCK1 | up-regulates activity
phosphorylation
|
SLC9A1 |
0.686 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279566 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27302366 |
We then engineered the T653A NHE1 mutant (ROCKA mutant), which can not be phosphorylated by p160ROCK.|p160ROCK has also been shown to activate NHE1 at threonine 653 , in close vicinity to the Akt phosphorylation site at serine 648. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SLC9A1 | up-regulates quantity
relocalization
|
sodium(1+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265600 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 31507243 |
Na+/H+ exchangers play pivotal roles in the control of cell and tissue pH by mediating the electroneutral exchange of Na+ and H+ across cellular membranes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
SLC9A1
- 
- 