| + |
AMPK | down-regulates activity 
phosphorylation
|
SLC9A3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277849 |
Ser555 |
AEGERRGsLAFIRSP |
Homo sapiens |
CACO-2 Cell |
| pmid |
sentence |
| 38047302 |
AMPK activation by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) phosphorylated NHE3 at S555. S555 is the primary site of phosphorylation by protein kinase A (PKA), but AMPK phosphorylated S555 independently of PKA. We conclude that AMPK activation inhibits NHE3 activity and NHE3 inhibition is associated with phosphorylation of NHE3 at S555 and S563. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277848 |
Ser563 |
LAFIRSPsTDNVVNV |
Homo sapiens |
CACO-2 Cell |
| pmid |
sentence |
| 38047302 |
AMPK activation by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) phosphorylated NHE3 at S555. S555 is the primary site of phosphorylation by protein kinase A (PKA), but AMPK phosphorylated S555 independently of PKA. We conclude that AMPK activation inhibits NHE3 activity and NHE3 inhibition is associated with phosphorylation of NHE3 at S555 and S563. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PKA | down-regulates activity
phosphorylation
|
SLC9A3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277847 |
Ser555 |
AEGERRGsLAFIRSP |
Homo sapiens |
CACO-2 Cell |
| pmid |
sentence |
| 38047302 |
AMPK activation by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) phosphorylated NHE3 at S555. S555 is the primary site of phosphorylation by protein kinase A (PKA), but AMPK phosphorylated S555 independently of PKA. We conclude that AMPK activation inhibits NHE3 activity and NHE3 inhibition is associated with phosphorylation of NHE3 at S555 and S563. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SGK1 | up-regulates activity 
phosphorylation
|
SLC9A3 |
0.434 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279112 |
Ser663 |
TMRKRLEsFKSTKLG |
Homo sapiens |
|
| pmid |
sentence |
| 21054167 |
The NHE3 activation by SGK1 is dependent on their combined interaction with NHERF2 and then phosphorylation at S663 of NHE3 by SGK1 ( xref , xref ). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SP1 | up-regulates quantity by expression 
transcriptional regulation
|
SLC9A3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254270 |
|
|
Drosophila melanogaster |
SCHNEIDER-2 Cell |
| pmid |
sentence |
| 16464174 |
Co-transfection of Sp1 or Sp3 into SL2 cells activated the NHE3-reporter constructs, suggesting that Sp1 and Sp3 act as positive regulators of the NHE3 expression. In addition, overexpression of EGR-1 was sufficient to transactivate the NHE3-reporter gene activity |
|
| Publications: |
1 |
Organism: |
Drosophila Melanogaster |
| + |
MAST2 | down-regulates activity
phosphorylation
|
SLC9A3 |
0.456 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279229 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16159897 |
Coexpression of MAST205 inhibits the activity of Na +/H+ exchanger NHE3.|Consistent with these results, we found that MAST205 phosphorylated NHE3 under in vitro conditions. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SP3 | up-regulates quantity by expression
transcriptional regulation
|
SLC9A3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254271 |
|
|
Drosophila melanogaster |
SCHNEIDER-2 Cell |
| pmid |
sentence |
| 16464174 |
Co-transfection of Sp1 or Sp3 into SL2 cells activated the NHE3-reporter constructs, suggesting that Sp1 and Sp3 act as positive regulators of the NHE3 expression. In addition, overexpression of EGR-1 was sufficient to transactivate the NHE3-reporter gene activity |
|
| Publications: |
1 |
Organism: |
Drosophila Melanogaster |
| + |
SLC9A3 | down-regulates quantity
relocalization
|
hydron |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265593 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 31507243 |
Na+/H+ exchangers play pivotal roles in the control of cell and tissue pH by mediating the electroneutral exchange of Na+ and H+ across cellular membranes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SLC9A3 | up-regulates quantity
relocalization
|
sodium(1+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265602 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 31507243 |
Na+/H+ exchangers play pivotal roles in the control of cell and tissue pH by mediating the electroneutral exchange of Na+ and H+ across cellular membranes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRKG2 | down-regulates activity
phosphorylation
|
SLC9A3 |
0.378 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280096 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25480791 |
CGMP and cGKII increased NHE3 phosphorylation at three sites (rabbit Ser (554), Ser (607), and Ser (663), equivalent to mouse Ser (552), Ser (605), and Ser (659)), all of which had to be present at the same time for cGMP to inhibit NHE3.|cGMP and cGKII rapidly inhibited NHE3, which was associated with reduced surface NHE3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EGR1 | up-regulates quantity by expression
transcriptional regulation
|
SLC9A3 |
0.246 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254269 |
|
|
Drosophila melanogaster |
SCHNEIDER-2 Cell |
| pmid |
sentence |
| 16464174 |
Transcriptional stimulation of the human NHE3 promoter activity by PMA: PKC independence and involvement of the transcription factor EGR-1|Co-transfection of Sp1 or Sp3 into SL2 cells activated the NHE3-reporter constructs, suggesting that Sp1 and Sp3 act as positive regulators of the NHE3 expression. In addition, overexpression of EGR-1 was sufficient to transactivate the NHE3-reporter gene activity |
|
| Publications: |
1 |
Organism: |
Drosophila Melanogaster |
4.0
SLC9A3
- 
- 