| + |
D-threo-isocitrate(3-) | up-regulates activity 
chemical activation
|
IDH2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267370 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32943735 |
Wild-type IDH1 and IDH2 catalyze the reaction by converting isocitrate and NADP+ into α-KG and CO2 with the concomitant generation of NADPH in the cytosol and mitochondrial matrix |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Citric acid cycle |
| + |
IDH2 | down-regulates quantity 
|
D-threo-isocitrate(3-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253136 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26178471 |
Isocitrate dehydrogenases (IDH) convert isocitrate to alpha-ketoglutarate (α-KG) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Citric acid cycle |
| + |
IDH | down-regulates quantity
chemical modification
|
D-threo-isocitrate(3-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266251 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28139779 |
Human NAD-dependent isocitrate dehydrogenase existing as the α2βγ heterotetramer, catalyzes the decarboxylation of isocitrate into α-ketoglutarate in the Krebs cycle, and is allosterically regulated by citrate, ADP and ATP. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Citric acid cycle |
| + |
D-threo-isocitrate(3-) | up-regulates quantity
precursor of
|
2-oxoglutarate(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266250 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28139779 |
Human NAD-dependent isocitrate dehydrogenase existing as the α2βγ heterotetramer, catalyzes the decarboxylation of isocitrate into α-ketoglutarate in the Krebs cycle, and is allosterically regulated by citrate, ADP and ATP. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Citric acid cycle |
| + |
IDH1 | down-regulates quantity
|
D-threo-isocitrate(3-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253137 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26178471 |
Isocitrate dehydrogenases (IDH) convert isocitrate to alpha-ketoglutarate (α-KG) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Citric acid cycle |
| + |
ACO2 | up-regulates quantity
chemical modification
|
D-threo-isocitrate(3-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266246 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24068518 |
Citrate is converted to cis-aconitate. This is catalyzed by aconitase. Cis-aconitate is an intermediate and is further converted to isocitrate by aconitase. Aconitase is involved in both reactions. In which first dehydration and then rehydration occur and as a result final product isocitrate is obtained. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Citric acid cycle |
| + |
ACO1 | up-regulates quantity
chemical modification
|
D-threo-isocitrate(3-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266245 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24068518 |
Citrate is converted to cis-aconitate. This is catalyzed by aconitase. Cis-aconitate is an intermediate and is further converted to isocitrate by aconitase. Aconitase is involved in both reactions. In which first dehydration and then rehydration occur and as a result final product isocitrate is obtained. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Citric acid cycle |
| + |
citrate(3-) | up-regulates quantity
precursor of
|
D-threo-isocitrate(3-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266241 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24068518 |
Citrate is converted to cis-aconitate. This is catalyzed by aconitase. Cis-aconitate is an intermediate and is further converted to isocitrate by aconitase. Aconitase is involved in both reactions. In which first dehydration and then rehydration occur and as a result final product isocitrate is obtained. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266243 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24068518 |
Citrate is converted to cis-aconitate. This is catalyzed by aconitase. Cis-aconitate is an intermediate and is further converted to isocitrate by aconitase. Aconitase is involved in both reactions. In which first dehydration and then rehydration occur and as a result final product isocitrate is obtained. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Citric acid cycle |
| + |
SLC25A1 | up-regulates quantity
relocalization
|
D-threo-isocitrate(3-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267290 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29651165 |
SLC25A1, a mitochondrial carrier that promotes the flux of citrate/isocitrate across the mitochondria, in exchange for the entry of cytosolic malate |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
D-threo-isocitrate(3-) | up-regulates activity
chemical activation
|
IDH1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267369 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32943735 |
Wild-type IDH1 and IDH2 catalyze the reaction by converting isocitrate and NADP+ into α-KG and CO2 with the concomitant generation of NADPH in the cytosol and mitochondrial matrix |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Citric acid cycle |
| + |
iron-sulfur cluster | up-regulates quantity
precursor of
|
D-threo-isocitrate(3-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262132 |
|
|
|
|
| pmid |
sentence |
| 26083061 |
Mitochondrial aconitase and succinate dehydrogenase were among the earliest mammalian Fe-S proteins identified.|The enzymatic activity of both proteins depends on the presence of intact Fe-S clusters |
|
| Publications: |
1 |
3.0
D-threo-isocitrate(3-)