| + |
CyclinA2/CDK2 | down-regulates quantity by destabilization 
phosphorylation
|
IDH1 |
0.273 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267621 |
Thr157 |
GKVEITYtPSDGTQK |
|
|
| pmid |
sentence |
| 34929314 |
During the cell cycle S phase, Cyclin A-CDK2 phosphorylates IDH1 on its Threonine 157 residue (Threonine 197 in IDH2) to facilitate its recognition and ubiquitination by Skp2 E3 ubiquitin, followed by degradation through 26S proteasome |
|
| Publications: |
1 |
| + |
FLT3 | up-regulates activity 
phosphorylation
|
IDH1 |
0.437 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267630 |
Tyr391 |
PNVQRSDyLNTFEFM |
in vitro |
|
| pmid |
sentence |
| 34289383 |
Moreover, in an in vitro kinase assay, purified recombinant FLT3 (rFLT3) phosphorylated recombinant IDH2 R140Q mutant but did not alter its catalytic activity (Figure 1C), whereas rFLT3 phosphorylated mIDH1 protein and enhanced its catalytic activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267629 |
Tyr42 |
VELDLHSyDLGIENR |
in vitro |
|
| pmid |
sentence |
| 34289383 |
Moreover, in an in vitro kinase assay, purified recombinant FLT3 (rFLT3) phosphorylated recombinant IDH2 R140Q mutant but did not alter its catalytic activity (Figure 1C), whereas rFLT3 phosphorylated mIDH1 protein and enhanced its catalytic activity |
|
| Publications: |
2 |
Organism: |
In Vitro |
| Pathways: | Acute Myeloid Leukemia, NPM1_new |
| + |
IDH1 | up-regulates quantity
chemical modification
|
2-oxoglutarate(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253135 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29090344 |
Two of the most commonly mutated genes in AML encode for two isoforms of isocitrate dehydrogenase (IDH), IDH1 and IDH2. IDH1 and IDH2 are two isoforms of isocitrate dehydrogenase that perform crucial roles in cellular metabolism. Somatic mutations in either of these two genes impart a neomorphic enzymatic activity upon the encoded enzymes resulting in the ability to convert α-ketoglutarate (αKG) into the oncometabolite R2-hydroxyglutarate (R2-HG), which can competitively inhibit multiple αKG-dependent dioxygenases. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261828 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26178471 |
Isocitrate dehydrogenases (IDH) convert isocitrate to alpha-ketoglutarate (α-KG) |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, DNMT3A in AML, AML-IDH/TET, IDH-TET in AML, Citric acid cycle, NPM1_new |
| + |
FOXO3 | up-regulates quantity by expression
transcriptional regulation
|
IDH1 |
0.251 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260100 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25648147 |
We identify FOXOs as transcriptional activators of IDH1. FOXOs promote IDH1 expression and thereby maintain the cytosolic levels of α-ketoglutarate and NADPH. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260089 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25648147 |
We identify FOXOs as transcriptional activators of IDH1. FOXOs promote IDH1 expression and thereby maintain the cytosolic levels of α-ketoglutarate and NADPH. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
FOXO6 | up-regulates quantity by expression
transcriptional regulation
|
IDH1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260092 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25648147 |
We identify FOXOs as transcriptional activators of IDH1. FOXOs promote IDH1 expression and thereby maintain the cytosolic levels of α-ketoglutarate and NADPH. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260103 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25648147 |
We identify FOXOs as transcriptional activators of IDH1. FOXOs promote IDH1 expression and thereby maintain the cytosolic levels of α-ketoglutarate and NADPH. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
FOXO | up-regulates quantity by expression
transcriptional regulation
|
IDH1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260088 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25648147 |
We identify FOXOs as transcriptional activators of IDH1. FOXOs promote IDH1 expression and thereby maintain the cytosolic levels of α-ketoglutarate and NADPH. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, IDH-TET in AML, NPM1_new |
| + |
FOXO1 | up-regulates quantity by expression
transcriptional regulation
|
IDH1 |
0.261 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260090 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25648147 |
We identify FOXOs as transcriptional activators of IDH1. FOXOs promote IDH1 expression and thereby maintain the cytosolic levels of α-ketoglutarate and NADPH. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260101 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25648147 |
We identify FOXOs as transcriptional activators of IDH1. FOXOs promote IDH1 expression and thereby maintain the cytosolic levels of α-ketoglutarate and NADPH. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
D-threo-isocitrate(3-) | up-regulates activity
chemical activation
|
IDH1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267369 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32943735 |
Wild-type IDH1 and IDH2 catalyze the reaction by converting isocitrate and NADP+ into α-KG and CO2 with the concomitant generation of NADPH in the cytosol and mitochondrial matrix |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Citric acid cycle |
| + |
SREBF2 | up-regulates quantity by expression
transcriptional regulation
|
IDH1 |
0.282 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253133 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12923220 |
IDH1 gene transcription is sterol regulated and activated by SREBP-1a and SREBP-2 in human hepatoma HepG2 cells|evidence that IDH1 may regulate lipogenesis in hepatic cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SREBF1 | up-regulates quantity by expression
transcriptional regulation
|
IDH1 |
0.286 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253132 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12923220 |
IDH1 gene transcription is sterol regulated and activated by SREBP-1a and SREBP-2 in human hepatoma HepG2 cells|evidence that IDH1 may regulate lipogenesis in hepatic cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IDH1 | down-regulates quantity
|
D-threo-isocitrate(3-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253137 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26178471 |
Isocitrate dehydrogenases (IDH) convert isocitrate to alpha-ketoglutarate (α-KG) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Citric acid cycle |
| + |
FOXO4 | up-regulates quantity by expression
transcriptional regulation
|
IDH1 |
0.267 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260102 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25648147 |
We identify FOXOs as transcriptional activators of IDH1. FOXOs promote IDH1 expression and thereby maintain the cytosolic levels of α-ketoglutarate and NADPH. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260091 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25648147 |
We identify FOXOs as transcriptional activators of IDH1. FOXOs promote IDH1 expression and thereby maintain the cytosolic levels of α-ketoglutarate and NADPH. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
SKP2 | down-regulates quantity by destabilization
ubiquitination
|
IDH1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267625 |
|
|
|
|
| pmid |
sentence |
| 34929314 |
During the cell cycle S phase, Cyclin A-CDK2 phosphorylates IDH1 on its Threonine 157 residue (Threonine 197 in IDH2) to facilitate its recognition and ubiquitination by Skp2 E3 ubiquitin, followed by degradation through 26S proteasome |
|
| Publications: |
1 |
| + |
SCF-SKP2 | down-regulates quantity by destabilization
ubiquitination
|
IDH1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267623 |
|
|
|
|
| pmid |
sentence |
| 34929314 |
During the cell cycle S phase, Cyclin A-CDK2 phosphorylates IDH1 on its Threonine 157 residue (Threonine 197 in IDH2) to facilitate its recognition and ubiquitination by Skp2 E3 ubiquitin, followed by degradation through 26S proteasome |
|
| Publications: |
1 |
3.0
IDH1
- 
- 