| + |
L-ornithine | up-regulates activity 
|
M2_polarization |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256075 |
|
|
|
|
| pmid |
sentence |
| 25386178 |
In general, M2 type macrophages act as anti-inflammatory cells via diversion of arginine away from NOS or via the synthesis of downstream products derived from the ornithine that is generated via arginase |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256076 |
|
|
|
|
| pmid |
sentence |
| 24669294 |
While investigating the factors that regulate macrophage arginine metabolism, Mills and colleagues found that macrophages activated in mouse strains with Th1 and Th2 backgrounds differed qualitatively in their ability to respond to the classic stimuli IFN-γ or lipopolysaccharide (LPS) or both and defined an important metabolic difference in the pathway: M1 macrophages made the toxic nitric oxide (NO), whereas M2 macrophages made the trophic polyamines |
|
| Publications: |
2 |
| + |
ARG1 | up-regulates quantity 
chemical modification
|
L-ornithine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255545 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14617280 |
Arginase generates ornithine, an aminoacid that can be further metabolized to proline via ornithine aminotransferase and to polyamines via ornithine decarboxylase (ODC) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
OAT | down-regulates quantity 
chemical modification
|
L-ornithine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256032 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14617280 |
Arginase generates ornithine, an aminoacid that can be further metabolized to proline via ornithine aminotransferase and to polyamines via ornithine decarboxylase (ODC) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ODC1 | down-regulates quantity
chemical modification
|
L-ornithine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256037 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14617280 |
Arginase generates ornithine, an aminoacid that can be further metabolized to proline via ornithine aminotransferase and to polyamines via ornithine decarboxylase (ODC) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
L-ornithine