| + |
IYD | down-regulates quantity 
chemical modification
|
3,5-diiodo-L-tyrosine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267036 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28153798 |
MIT and DIT, which are deiodinated by iodotyrosine dehalogenase (DEHAL1) that seems to be present in the apical plasma membrane. MIT and DIT are liberated, and the deiodination of these molecules by DEHAL1 is important for providing a sustained source of intrathyroidal iodide. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid Hormone Metabolism |
| + |
3-iodo-L-tyrosine | up-regulates quantity 
precursor of
|
3,5-diiodo-L-tyrosine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267037 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28153798 |
The synthesis of T3 and T4 is achieved through the transfer of an iodophenoxyl group from a MIT or DIT residue called a “donor” onto a DIT residue called an “acceptor”. TPO seems to be primarily responsible for catalyzing the oxidations of iodotyrosines. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid Hormone Metabolism |
| + |
3,5-diiodo-L-tyrosine | up-regulates quantity
precursor of
|
L-tyrosine zwitterion |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267035 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28153798 |
MIT and DIT, which are deiodinated by iodotyrosine dehalogenase (DEHAL1) that seems to be present in the apical plasma membrane. MIT and DIT are liberated, and the deiodination of these molecules by DEHAL1 is important for providing a sustained source of intrathyroidal iodide. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid Hormone Metabolism |
| + |
iodide | up-regulates quantity
precursor of
|
3,5-diiodo-L-tyrosine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259913 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23349248 |
After transport through the apical membrane, I‚àí is covalently bound to the tyrosyl residues of Tg by thyroid peroxidase (TPO). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266958 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16098474 |
TPO plays a key role in thyroid hormone synthesis by catalyzing both the iodination of tyrosine residues to form monoiodotyrosine (MIT) and diiodotyrosine (DIT) residues. The first step in the process of thyroid hormone synthesis is the binding of iodine to tyrosine residues in Tg, which yields MIT and DIT residues. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid cancer, Thyroid Hormone Metabolism |
| + |
3,5-diiodo-L-tyrosine | up-regulates quantity
precursor of
|
L-alanine zwitterion |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268122 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28153798 |
The synthesis of T3 and T4 is achieved through the transfer of an iodophenoxyl group from a MIT or DIT residue called a “donor” onto a DIT residue called an “acceptor”. TPO seems to be primarily responsible for catalyzing the oxidations of iodotyrosines. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid Hormone Metabolism |
| + |
3,5-diiodo-L-tyrosine | up-regulates quantity
precursor of
|
3,3',5'-triiodothyronine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268121 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28153798 |
The synthesis of T3 and T4 is achieved through the transfer of an iodophenoxyl group from a MIT or DIT residue called a “donor” onto a DIT residue called an “acceptor”. TPO seems to be primarily responsible for catalyzing the oxidations of iodotyrosines. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid Hormone Metabolism |
| + |
3,5-diiodo-L-tyrosine | up-regulates quantity
precursor of
|
iodide |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268093 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28153798 |
MIT and DIT, which are deiodinated by iodotyrosine dehalogenase (DEHAL1) that seems to be present in the apical plasma membrane. MIT and DIT are liberated, and the deiodination of these molecules by DEHAL1 is important for providing a sustained source of intrathyroidal iodide. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid cancer, Thyroid Hormone Metabolism |
| + |
3,5-diiodo-L-tyrosine | up-regulates quantity
precursor of
|
L-thyroxine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267038 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28153798 |
The synthesis of T3 and T4 is achieved through the transfer of an iodophenoxyl group from a MIT or DIT residue called a “donor” onto a DIT residue called an “acceptor”. TPO seems to be primarily responsible for catalyzing the oxidations of iodotyrosines. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid Hormone Metabolism |
| + |
TPO | up-regulates quantity
chemical modification
|
3,5-diiodo-L-tyrosine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267030 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16098474 |
TPO plays a key role in thyroid hormone synthesis by catalyzing both the iodination of tyrosine residues to form monoiodotyrosine (MIT) and diiodotyrosine (DIT) residues. The first step in the process of thyroid hormone synthesis is the binding of iodine to tyrosine residues in Tg, which yields MIT and DIT residues. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid cancer, Thyroid Hormone Metabolism |
3.0
3,5-diiodo-L-tyrosine