| + |
L-thyroxine | up-regulates quantity 
precursor of
|
iodide |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268126 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34674502 |
Thyroid hormone (TH) deiodinases play a pivotal role in the functional diversification of TH signaling. They are involved in development, growth, and metabolic processes, and act in a cell-specific manner in the fine regulation of TH homeostasis. TH deiodinases catalyze activation and inactivation of THs through the removal of one iodine atom in the outer or inner ring of the TH molecule.  |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266946 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12746313 |
Human type III iodothyronine deiodinase (D3) catalyzes the conversion of T(4) to rT(3) and of T(3) to 3, 3'-diiodothyronine (T2) by inner-ring deiodination. Like types I and II iodothyronine deiodinases, D3 protein contains selenocysteine (SeC) in the highly conserved core catalytic center at amino acid position 144. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266950 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8755651 |
Type II iodothyronine deiodinase (DII), which catalyzes deiodination of thyroxine (T4) exclusively on the outer ring (5’-position) to yield T3 |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid Hormone Metabolism |
| + |
iodide | up-regulates quantity
precursor of
|
3,5-diiodo-L-tyrosine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259913 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23349248 |
After transport through the apical membrane, I‚àí is covalently bound to the tyrosyl residues of Tg by thyroid peroxidase (TPO). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266958 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16098474 |
TPO plays a key role in thyroid hormone synthesis by catalyzing both the iodination of tyrosine residues to form monoiodotyrosine (MIT) and diiodotyrosine (DIT) residues. The first step in the process of thyroid hormone synthesis is the binding of iodine to tyrosine residues in Tg, which yields MIT and DIT residues. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid cancer, Thyroid Hormone Metabolism |
| + |
IYD | up-regulates quantity
chemical modification
|
iodide |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267034 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28153798 |
MIT and DIT, which are deiodinated by iodotyrosine dehalogenase (DEHAL1) that seems to be present in the apical plasma membrane. MIT and DIT are liberated, and the deiodination of these molecules by DEHAL1 is important for providing a sustained source of intrathyroidal iodide. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid Hormone Metabolism |
| + |
DIO | up-regulates quantity
chemical modification
|
iodide |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267045 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34674502 |
Thyroid hormone (TH) deiodinases play a pivotal role in the functional diversification of TH signaling. They are involved in development, growth, and metabolic processes, and act in a cell-specific manner in the fine regulation of TH homeostasis. TH deiodinases catalyze activation and inactivation of THs through the removal of one iodine atom in the outer or inner ring of the TH molecule.  |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
3-iodo-L-tyrosine | up-regulates quantity
precursor of
|
iodide |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268094 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28153798 |
MIT and DIT, which are deiodinated by iodotyrosine dehalogenase (DEHAL1) that seems to be present in the apical plasma membrane. MIT and DIT are liberated, and the deiodination of these molecules by DEHAL1 is important for providing a sustained source of intrathyroidal iodide. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid Hormone Metabolism |
| + |
iodide | up-regulates activity
chemical activation
|
TPO |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268139 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23349248 |
After transport through the apical membrane, Iodide is covalently bound to the tyrosyl residues of Tg by thyroid peroxidase (TPO). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Thyroid Follicle |
| Pathways: | Thyroid cancer, Thyroid Hormone Metabolism |
| + |
DIO3 | up-regulates quantity
chemical modification
|
iodide |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266952 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34674502 |
Three different deiodinases have been described: iodothyronine deiodinase 1 (DIO1), DIO2, and DIO3. Deiodination is the first step in the activation/inactivation process of THs and involves the removal of removes one iodine atom from the outer tyrosyl ring of T4 to produce T3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid Hormone Metabolism |
| + |
3,5-diiodo-L-tyrosine | up-regulates quantity
precursor of
|
iodide |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268093 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28153798 |
MIT and DIT, which are deiodinated by iodotyrosine dehalogenase (DEHAL1) that seems to be present in the apical plasma membrane. MIT and DIT are liberated, and the deiodination of these molecules by DEHAL1 is important for providing a sustained source of intrathyroidal iodide. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid cancer, Thyroid Hormone Metabolism |
| + |
SLC5A5 | up-regulates activity
chemical activation
|
iodide |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251996 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14623893 |
Iodide is an essential element in thyroid physiology as a critical component of thyroxine and triiodothyronine molecules and a key regulator of thyroid gland function. The first step in iodide metabolism is represented by thyroid trapping, which is achieved by an active, energy-dependent transport process across the basolateral plasma membrane of the thyrocytes. The protein responsible for this process, the sodium/iodide symporter (NIS),1 is an intrinsic plasma membrane protein that mediates active transport of I- in the thyroid, lactating mammary gland, stomach, and salivary glands |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid cancer, Thyroid Hormone Metabolism |
| + |
DIO1 | up-regulates quantity
chemical modification
|
iodide |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266954 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34674502 |
Three different deiodinases have been described: iodothyronine deiodinase 1 (DIO1), DIO2, and DIO3. Deiodination is the first step in the activation/inactivation process of THs and involves the removal of removes one iodine atom from the outer tyrosyl ring of T4 to produce T3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid Hormone Metabolism |
| + |
iodide | up-regulates quantity
precursor of
|
3-iodo-L-tyrosine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268120 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16098474 |
TPO plays a key role in thyroid hormone synthesis by catalyzing both the iodination of tyrosine residues to form monoiodotyrosine (MIT) and diiodotyrosine (DIT) residues. The first step in the process of thyroid hormone synthesis is the binding of iodine to tyrosine residues in Tg, which yields MIT and DIT residues. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid Hormone Metabolism |
| + |
SLC5A5 | up-regulates quantity
relocalization
|
iodide |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266960 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 28192058 |
Active iodide (I-) transport in both the thyroid and some extrathyroidal tissues is mediated by the Na+/I- symporter (NIS). In the thyroid, NIS-mediated I- uptake plays a pivotal role in thyroid hormone (TH) biosynthesis. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| Pathways: | Thyroid cancer, Thyroid Hormone Metabolism |
| + |
iodide | up-regulates quantity
precursor of
|
diiodine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268119 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23349248 |
After transport through the apical membrane, I‚àí is covalently bound to the tyrosyl residues of Tg by thyroid peroxidase (TPO). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DIO2 | up-regulates quantity
chemical modification
|
iodide |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266953 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34674502 |
Three different deiodinases have been described: iodothyronine deiodinase 1 (DIO1), DIO2, and DIO3. Deiodination is the first step in the activation/inactivation process of THs and involves the removal of removes one iodine atom from the outer tyrosyl ring of T4 to produce T3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid Hormone Metabolism |
3.0
iodide