Summary

Name DIO3
Full Name Thyroxine 5-deiodinase
Synonyms 5DIII, DIOIII, Type 3 DI, Type III iodothyronine deiodinase | ITDI3, TXDI3
Primary ID P55073
Links - -
Type protein
Relations 3
Pathways Thyroid Hormone Metabolism
Function Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development.

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Relations

Regulator Mechanism target score ℹ
+ DIO3up-regulates quantity img/direct-activation.png chemical modification iodide 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Thyroid Hormone Metabolism
+ DIO3down-regulates quantity img/direct_inhibition.png chemical modification L-thyroxine 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Thyroid Hormone Metabolism
+ DIO3up-regulates quantity img/direct-activation.png chemical modification 3,3',5'-triiodothyronine 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Thyroid Hormone Metabolism