| + |
androst-4-ene-3,17-dione | up-regulates quantity 
precursor of
|
testosterone |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268665 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16166196 |
A novel 17beta-hydroxysteroid dehydrogenase (17beta-HSD) chronologically named type 12 17beta-HSD (17beta-HSD12), that transforms estrone (E1) into estradiol (E2) was identified by sequence similarity with type 3 17beta-HSD (17beta-HSD3) that catalyzes the formation of testosterone from androstenedione in the testis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Testis |
| Pathways: | Sex Hormone Biosynthesis |
| + |
CYP19A1 | down-regulates quantity 
chemical modification
|
androst-4-ene-3,17-dione |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268672 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27702664 |
The cytochrome P450 aromatase is involved in the last step of sex hormones biosynthesis by converting androgens into estrogens. |Human aromatase (CYP19A1) is a membrane-bound class II cytochrome P450 that converts androgens into estrogens [1], [2], [3], [4]. Specifically, the enzyme is involved sex hormones biosynthesis where it is responsible for the conversion of androstenedione, testosterone and 16alpha-hydroxytestosterone into estrone, estradiol and estriol, respectively |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Ovary |
| Pathways: | Sex Hormone Biosynthesis |
| + |
androst-4-ene-3,17-dione | up-regulates quantity
precursor of
|
estrone |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268668 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27702664 |
The cytochrome P450 aromatase is involved in the last step of sex hormones biosynthesis by converting androgens into estrogens. |Human aromatase (CYP19A1) is a membrane-bound class II cytochrome P450 that converts androgens into estrogens [1], [2], [3], [4]. Specifically, the enzyme is involved sex hormones biosynthesis where it is responsible for the conversion of androstenedione, testosterone and 16alpha-hydroxytestosterone into estrone, estradiol and estriol, respectively |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Ovary |
| Pathways: | Sex Hormone Biosynthesis |
| + |
HSD3B1 | up-regulates quantity
chemical modification
|
androst-4-ene-3,17-dione |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268638 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 2139411 |
The isolation, cloning, and expression of a cDNA insert complementary to mRNA encoding human 3 beta-hydroxysteroid dehydrogenase/delta 5----4isomerase is reported. |The expressed protein was similar in size to human placental microsomal 3 beta-hydroxysteroid dehydrogenase/delta 5----4isomerase, as detected by immunoblot analysis, and catalyzed the conversion of 17 alpha-hydroxypregnenolone to 17 alpha-hydroxyprogesterone, pregnenolone to progesterone, and dehydroepiandrosterone to androstenedione. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Zona Reticulata |
| Pathways: | Sex Hormone Biosynthesis |
| + |
17alpha-hydroxyprogesterone | up-regulates quantity
precursor of
|
androst-4-ene-3,17-dione |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268650 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17192295 |
THE MICROSOMAL ENZYME P450c17 catalyzes two reactions: the 17α-hydroxylation of progesterone and pregnenolone and the subsequent cleavage of the C17–20 carbon bond to produce dehydroepiandrosterone (DHEA) and androstenedione. Whereas only 17α-hydroxylase activity is necessary for the production of corticosteroids, both activities of P450c17 are required to synthesize sex hormones. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Testis, Zona Fasciculata, Zona Reticulata |
| Pathways: | Sex Hormone Biosynthesis |
| + |
dehydroepiandrosterone | up-regulates quantity
precursor of
|
androst-4-ene-3,17-dione |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268641 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 2139411 |
The isolation, cloning, and expression of a cDNA insert complementary to mRNA encoding human 3 beta-hydroxysteroid dehydrogenase/delta 5----4isomerase is reported. |The expressed protein was similar in size to human placental microsomal 3 beta-hydroxysteroid dehydrogenase/delta 5----4isomerase, as detected by immunoblot analysis, and catalyzed the conversion of 17 alpha-hydroxypregnenolone to 17 alpha-hydroxyprogesterone, pregnenolone to progesterone, and dehydroepiandrosterone to androstenedione. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Zona Reticulata |
| Pathways: | Sex Hormone Biosynthesis |
| + |
CYP17A1 | up-regulates quantity
chemical modification
|
androst-4-ene-3,17-dione |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268654 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17192295 |
THE MICROSOMAL ENZYME P450c17 catalyzes two reactions: the 17α-hydroxylation of progesterone and pregnenolone and the subsequent cleavage of the C17–20 carbon bond to produce dehydroepiandrosterone (DHEA) and androstenedione. Whereas only 17α-hydroxylase activity is necessary for the production of corticosteroids, both activities of P450c17 are required to synthesize sex hormones. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Testis, Zona Fasciculata, Zona Reticulata |
| Pathways: | Sex Hormone Biosynthesis |
3.0
androst-4-ene-3,17-dione