| + |
HSD3B1 | up-regulates quantity 
chemical modification
|
progesterone |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268635 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 2243100 |
Three beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase (3 beta-HSD) catalyze the oxidative conversion of delta 5-3 beta-hydroxysteroids to the delta 4-3-keto configuration and is therefore essential for the biosynthesis of all classes of hormonal steroids, namely progesterone, glucocorticoids, mineralocorticoids, androgens, and estrogens. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Zona Glomerulosa |
| Pathways: | Sex Hormone Biosynthesis |
| + |
HSD3B1 | up-regulates quantity
chemical modification
|
17alpha-hydroxyprogesterone |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268636 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 2139411 |
The isolation, cloning, and expression of a cDNA insert complementary to mRNA encoding human 3 beta-hydroxysteroid dehydrogenase/delta 5----4isomerase is reported. |The expressed protein was similar in size to human placental microsomal 3 beta-hydroxysteroid dehydrogenase/delta 5----4isomerase, as detected by immunoblot analysis, and catalyzed the conversion of 17 alpha-hydroxypregnenolone to 17 alpha-hydroxyprogesterone, pregnenolone to progesterone, and dehydroepiandrosterone to androstenedione. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Zona Fasciculata |
| Pathways: | Sex Hormone Biosynthesis |
| + |
HSD3B1 | up-regulates quantity
chemical modification
|
androst-4-ene-3,17-dione |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268638 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 2139411 |
The isolation, cloning, and expression of a cDNA insert complementary to mRNA encoding human 3 beta-hydroxysteroid dehydrogenase/delta 5----4isomerase is reported. |The expressed protein was similar in size to human placental microsomal 3 beta-hydroxysteroid dehydrogenase/delta 5----4isomerase, as detected by immunoblot analysis, and catalyzed the conversion of 17 alpha-hydroxypregnenolone to 17 alpha-hydroxyprogesterone, pregnenolone to progesterone, and dehydroepiandrosterone to androstenedione. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Zona Reticulata |
| Pathways: | Sex Hormone Biosynthesis |
| + |
Corticotropin | up-regulates quantity 
|
HSD3B1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268720 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24631756 |
CTH signaling promotes the single steroidogenic rate limiting step, which is the conversion of cholesterol to pregnenolone by Cholesterol Side-Chain Cleavage Enzyme (P450scc), encoded in the CYP11A1 gene. This is conferred by a direct stimulating effect of ACTH on the promoter of CYP11A1 (Chung et al., 1997, Liu and Simpson, 1997, Hu et al., 2001). Further, it stimulates conversion of pregnenolone to 17-hydroxypregnenolone by upregulating the expression of 3β hydroxysteroid dehydrogenase enzyme (3β-HSD) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HSD3B1 | up-regulates quantity
chemical modification
|
testosterone |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268637 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 1537836 |
We have recently characterized two types of rat 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase (3 beta-HSD) isoenzymes expressed in adrenals and gonads. | However, in the presence of NADH, type III isoenzyme, in common with the type I isoform, converts 5 alpha-androstane-3,17-dione (A-dione) and 5 alpha-dihydrotestosterone (DHT) to the corresponding 3 beta-hydroxysteroids. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| Tissue: |
Gonad, Zona Reticulata |
| Pathways: | Sex Hormone Biosynthesis |
3.0
HSD3B1
- 
- 