| + |
CYP17A1 | down-regulates quantity 
chemical modification
|
17alpha-hydroxypregnenolone |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268655 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17192295 |
THE MICROSOMAL ENZYME P450c17 catalyzes two reactions: the 17α-hydroxylation of progesterone and pregnenolone and the subsequent cleavage of the C17–20 carbon bond to produce dehydroepiandrosterone (DHEA) and androstenedione. Whereas only 17α-hydroxylase activity is necessary for the production of corticosteroids, both activities of P450c17 are required to synthesize sex hormones. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Testis, Zona Fasciculata, Zona Reticulata |
| Pathways: | Sex Hormone Biosynthesis |
| + |
CYP17A1 | down-regulates quantity
chemical modification
|
pregnenolone |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268656 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17192295 |
THE MICROSOMAL ENZYME P450c17 catalyzes two reactions: the 17α-hydroxylation of progesterone and pregnenolone and the subsequent cleavage of the C17–20 carbon bond to produce dehydroepiandrosterone (DHEA) and androstenedione. Whereas only 17α-hydroxylase activity is necessary for the production of corticosteroids, both activities of P450c17 are required to synthesize sex hormones. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Testis, Zona Glomerulosa, Zona Fasciculata |
| Pathways: | Sex Hormone Biosynthesis |
| + |
CYP17A1 | down-regulates quantity
chemical modification
|
17alpha-hydroxyprogesterone |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268658 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17192295 |
THE MICROSOMAL ENZYME P450c17 catalyzes two reactions: the 17α-hydroxylation of progesterone and pregnenolone and the subsequent cleavage of the C17–20 carbon bond to produce dehydroepiandrosterone (DHEA) and androstenedione. Whereas only 17α-hydroxylase activity is necessary for the production of corticosteroids, both activities of P450c17 are required to synthesize sex hormones. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Testis, Zona Fasciculata, Zona Reticulata |
| Pathways: | Sex Hormone Biosynthesis |
| + |
CYP17A1 | down-regulates quantity
chemical modification
|
progesterone |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268657 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17192295 |
THE MICROSOMAL ENZYME P450c17 catalyzes two reactions: the 17α-hydroxylation of progesterone and pregnenolone and the subsequent cleavage of the C17–20 carbon bond to produce dehydroepiandrosterone (DHEA) and androstenedione. Whereas only 17α-hydroxylase activity is necessary for the production of corticosteroids, both activities of P450c17 are required to synthesize sex hormones. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Testis, Zona Glomerulosa, Zona Fasciculata |
| Pathways: | Sex Hormone Biosynthesis |
| + |
CYP17A1 | up-regulates quantity 
chemical modification
|
17alpha-hydroxyprogesterone |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268653 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17192295 |
THE MICROSOMAL ENZYME P450c17 catalyzes two reactions: the 17α-hydroxylation of progesterone and pregnenolone and the subsequent cleavage of the C17–20 carbon bond to produce dehydroepiandrosterone (DHEA) and androstenedione. Whereas only 17α-hydroxylase activity is necessary for the production of corticosteroids, both activities of P450c17 are required to synthesize sex hormones. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Testis, Zona Glomerulosa, Zona Fasciculata |
| Pathways: | Sex Hormone Biosynthesis |
| + |
CYP17A1 | up-regulates quantity
chemical modification
|
17alpha-hydroxypregnenolone |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268652 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17192295 |
THE MICROSOMAL ENZYME P450c17 catalyzes two reactions: the 17α-hydroxylation of progesterone and pregnenolone and the subsequent cleavage of the C17–20 carbon bond to produce dehydroepiandrosterone (DHEA) and androstenedione. Whereas only 17α-hydroxylase activity is necessary for the production of corticosteroids, both activities of P450c17 are required to synthesize sex hormones. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Testis, Zona Glomerulosa, Zona Fasciculata |
| Pathways: | Sex Hormone Biosynthesis |
| + |
CYP17A1 | up-regulates quantity
chemical modification
|
androst-4-ene-3,17-dione |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268654 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17192295 |
THE MICROSOMAL ENZYME P450c17 catalyzes two reactions: the 17α-hydroxylation of progesterone and pregnenolone and the subsequent cleavage of the C17–20 carbon bond to produce dehydroepiandrosterone (DHEA) and androstenedione. Whereas only 17α-hydroxylase activity is necessary for the production of corticosteroids, both activities of P450c17 are required to synthesize sex hormones. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Testis, Zona Fasciculata, Zona Reticulata |
| Pathways: | Sex Hormone Biosynthesis |
| + |
abiraterone acetate | down-regulates
chemical inhibition
|
CYP17A1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-205573 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| Other |
|
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TFEB | up-regulates quantity by expression 
transcriptional regulation
|
CYP17A1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276786 |
|
|
|
|
| pmid |
sentence |
| 33176151 |
Among the differentially expressed genes, we detected upregulation of known targets in TFEB-WT and TFEB-nuc cells (Figure 2B; Tables S1 and S2), including genes functioning in lysosomal and autophagy pathways|Using quantitative PCR (qPCR), we validated expression patterns observed by RNA sequencing for selected genes (CTSD, SQSTM1, MCOLN1, IL33, FAP, GPNMB, IFI30, FOLR1, and G0S2) |
|
| Publications: |
1 |
| + |
CYP17A1 | up-regulates quantity
chemical modification
|
dehydroepiandrosterone |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268651 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17192295 |
THE MICROSOMAL ENZYME P450c17 catalyzes two reactions: the 17α-hydroxylation of progesterone and pregnenolone and the subsequent cleavage of the C17–20 carbon bond to produce dehydroepiandrosterone (DHEA) and androstenedione. Whereas only 17α-hydroxylase activity is necessary for the production of corticosteroids, both activities of P450c17 are required to synthesize sex hormones. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Testis, Zona Fasciculata, Zona Reticulata |
| Pathways: | Sex Hormone Biosynthesis |
| + |
6-(7-hydroxy-5,6-dihydropyrrolo[1,2-c]imidazol-7-yl)-N-methyl-2-naphthalenecarboxamide | down-regulates
chemical inhibition
|
CYP17A1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-207141 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| Other |
|
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GATA6 | up-regulates quantity by expression
transcriptional regulation
|
CYP17A1 |
0.353 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254198 |
|
|
Homo sapiens |
Theca Cell |
| pmid |
sentence |
| 15284005 |
The transcription factor GATA6, which regulates the promoter activity of CYP17 and CYP11A, was increased in the PCOS compared to normal theca cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Ovary |
| + |
abiraterone | down-regulates
chemical inhibition
|
CYP17A1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-204810 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| Other |
|
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
CYP17A1
- 
- 