| + |
testosterone | up-regulates activity 
chemical activation
|
SRD5A1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251532 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15861399 |
Testosterone is the predominant circulating androgen in mammals and is converted to dihydrotestosterone (DHT) by 5α-reductase in certain tissues of the male urogenital tract, skin, and other target cells. DHT binds with highest affinity to AR and together with testosterone promotes AR transcriptional activity thereby ensuring the development and maintenance of male reproductive functions. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
testosterone | up-regulates quantity
precursor of
|
17beta-estradiol |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268667 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27702664 |
The cytochrome P450 aromatase is involved in the last step of sex hormones biosynthesis by converting androgens into estrogens. |Human aromatase (CYP19A1) is a membrane-bound class II cytochrome P450 that converts androgens into estrogens [1], [2], [3], [4]. Specifically, the enzyme is involved sex hormones biosynthesis where it is responsible for the conversion of androstenedione, testosterone and 16alpha-hydroxytestosterone into estrone, estradiol and estriol, respectively |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Ovary |
| Pathways: | Sex Hormone Biosynthesis |
| + |
androst-4-ene-3,17-dione | up-regulates quantity
precursor of
|
testosterone |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268665 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16166196 |
A novel 17beta-hydroxysteroid dehydrogenase (17beta-HSD) chronologically named type 12 17beta-HSD (17beta-HSD12), that transforms estrone (E1) into estradiol (E2) was identified by sequence similarity with type 3 17beta-HSD (17beta-HSD3) that catalyzes the formation of testosterone from androstenedione in the testis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Testis |
| Pathways: | Sex Hormone Biosynthesis |
| + |
CYP19A1 | down-regulates quantity 
chemical modification
|
testosterone |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268671 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27702664 |
The cytochrome P450 aromatase is involved in the last step of sex hormones biosynthesis by converting androgens into estrogens. |Human aromatase (CYP19A1) is a membrane-bound class II cytochrome P450 that converts androgens into estrogens [1], [2], [3], [4]. Specifically, the enzyme is involved sex hormones biosynthesis where it is responsible for the conversion of androstenedione, testosterone and 16alpha-hydroxytestosterone into estrone, estradiol and estriol, respectively |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Ovary |
| Pathways: | Sex Hormone Biosynthesis |
| + |
HSD17B11 | up-regulates quantity
chemical modification
|
testosterone |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268666 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16166196 |
A novel 17beta-hydroxysteroid dehydrogenase (17beta-HSD) chronologically named type 12 17beta-HSD (17beta-HSD12), that transforms estrone (E1) into estradiol (E2) was identified by sequence similarity with type 3 17beta-HSD (17beta-HSD3) that catalyzes the formation of testosterone from androstenedione in the testis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Zona Reticulata |
| Pathways: | Sex Hormone Biosynthesis |
| + |
HSD3B1 | up-regulates quantity
chemical modification
|
testosterone |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268637 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 1537836 |
We have recently characterized two types of rat 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase (3 beta-HSD) isoenzymes expressed in adrenals and gonads. | However, in the presence of NADH, type III isoenzyme, in common with the type I isoform, converts 5 alpha-androstane-3,17-dione (A-dione) and 5 alpha-dihydrotestosterone (DHT) to the corresponding 3 beta-hydroxysteroids. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| Tissue: |
Gonad, Zona Reticulata |
| Pathways: | Sex Hormone Biosynthesis |
| + |
testosterone | up-regulates activity
chemical activation
|
AR |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251553 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15861399 |
Testosterone is the predominant circulating androgen in mammals and is converted to dihydrotestosterone (DHT) by 5α-reductase in certain tissues of the male urogenital tract, skin, and other target cells. DHT binds with highest affinity to AR and together with testosterone promotes AR transcriptional activity thereby ensuring the development and maintenance of male reproductive functions. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
androst-5-ene-3beta,17beta-diol | up-regulates quantity
precursor of
|
testosterone |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268640 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 1537836 |
We have recently characterized two types of rat 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase (3 beta-HSD) isoenzymes expressed in adrenals and gonads. | However, in the presence of NADH, type III isoenzyme, in common with the type I isoform, converts 5 alpha-androstane-3,17-dione (A-dione) and 5 alpha-dihydrotestosterone (DHT) to the corresponding 3 beta-hydroxysteroids. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| Tissue: |
Gonad, Zona Reticulata |
| Pathways: | Sex Hormone Biosynthesis |
3.0
testosterone