| + |
17alpha-hydroxyprogesterone | up-regulates quantity 
precursor of
|
androst-4-ene-3,17-dione |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268650 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17192295 |
THE MICROSOMAL ENZYME P450c17 catalyzes two reactions: the 17α-hydroxylation of progesterone and pregnenolone and the subsequent cleavage of the C17–20 carbon bond to produce dehydroepiandrosterone (DHEA) and androstenedione. Whereas only 17α-hydroxylase activity is necessary for the production of corticosteroids, both activities of P450c17 are required to synthesize sex hormones. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Testis, Zona Fasciculata, Zona Reticulata |
| Pathways: | Sex Hormone Biosynthesis |
| + |
17alpha-hydroxyprogesterone | up-regulates quantity
precursor of
|
11-deoxycortisol |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268642 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25855791 |
Cytochrome P450 (P450)4 21A2 is the major steroid 21-hydroxylase, which catalyzes the 21-hydroxylation of progesterone and 17alpha-hydroxyprogesterone (17alpha-OH-progesterone) to form 11-deoxycorticosterone and 11-deoxycortisol, respectively |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Zona Fasciculata |
| Pathways: | Sex Hormone Biosynthesis |
| + |
HSD3B1 | up-regulates quantity
chemical modification
|
17alpha-hydroxyprogesterone |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268636 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 2139411 |
The isolation, cloning, and expression of a cDNA insert complementary to mRNA encoding human 3 beta-hydroxysteroid dehydrogenase/delta 5----4isomerase is reported. |The expressed protein was similar in size to human placental microsomal 3 beta-hydroxysteroid dehydrogenase/delta 5----4isomerase, as detected by immunoblot analysis, and catalyzed the conversion of 17 alpha-hydroxypregnenolone to 17 alpha-hydroxyprogesterone, pregnenolone to progesterone, and dehydroepiandrosterone to androstenedione. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Zona Fasciculata |
| Pathways: | Sex Hormone Biosynthesis |
| + |
CYP17A1 | down-regulates quantity 
chemical modification
|
17alpha-hydroxyprogesterone |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268658 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17192295 |
THE MICROSOMAL ENZYME P450c17 catalyzes two reactions: the 17α-hydroxylation of progesterone and pregnenolone and the subsequent cleavage of the C17–20 carbon bond to produce dehydroepiandrosterone (DHEA) and androstenedione. Whereas only 17α-hydroxylase activity is necessary for the production of corticosteroids, both activities of P450c17 are required to synthesize sex hormones. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Testis, Zona Fasciculata, Zona Reticulata |
| Pathways: | Sex Hormone Biosynthesis |
| + |
progesterone | up-regulates quantity
precursor of
|
17alpha-hydroxyprogesterone |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268649 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17192295 |
THE MICROSOMAL ENZYME P450c17 catalyzes two reactions: the 17α-hydroxylation of progesterone and pregnenolone and the subsequent cleavage of the C17–20 carbon bond to produce dehydroepiandrosterone (DHEA) and androstenedione. Whereas only 17α-hydroxylase activity is necessary for the production of corticosteroids, both activities of P450c17 are required to synthesize sex hormones. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Testis, Zona Glomerulosa, Zona Fasciculata |
| Pathways: | Sex Hormone Biosynthesis |
| + |
CYP17A1 | up-regulates quantity
chemical modification
|
17alpha-hydroxyprogesterone |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268653 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17192295 |
THE MICROSOMAL ENZYME P450c17 catalyzes two reactions: the 17α-hydroxylation of progesterone and pregnenolone and the subsequent cleavage of the C17–20 carbon bond to produce dehydroepiandrosterone (DHEA) and androstenedione. Whereas only 17α-hydroxylase activity is necessary for the production of corticosteroids, both activities of P450c17 are required to synthesize sex hormones. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Testis, Zona Glomerulosa, Zona Fasciculata |
| Pathways: | Sex Hormone Biosynthesis |
| + |
17alpha-hydroxypregnenolone | up-regulates quantity
precursor of
|
17alpha-hydroxyprogesterone |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268639 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 2139411 |
The isolation, cloning, and expression of a cDNA insert complementary to mRNA encoding human 3 beta-hydroxysteroid dehydrogenase/delta 5----4isomerase is reported. |The expressed protein was similar in size to human placental microsomal 3 beta-hydroxysteroid dehydrogenase/delta 5----4isomerase, as detected by immunoblot analysis, and catalyzed the conversion of 17 alpha-hydroxypregnenolone to 17 alpha-hydroxyprogesterone, pregnenolone to progesterone, and dehydroepiandrosterone to androstenedione. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Zona Fasciculata |
| Pathways: | Sex Hormone Biosynthesis |
| + |
CYP21A2 | up-regulates quantity
chemical modification
|
17alpha-hydroxyprogesterone |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268643 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25855791 |
Cytochrome P450 (P450)4 21A2 is the major steroid 21-hydroxylase, which catalyzes the 21-hydroxylation of progesterone and 17alpha-hydroxyprogesterone (17alpha-OH-progesterone) to form 11-deoxycorticosterone and 11-deoxycortisol, respectively |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Zona Fasciculata |
| Pathways: | Sex Hormone Biosynthesis |
3.0
17alpha-hydroxyprogesterone