Relation Results

Summary

Name diisononyl phthalate
Synonyms 1,2-Benzenedicarboxylic acid, diisononyl ester (ChemIDplus), Diisononyl phthalate (KEGG COMPOUND), Enj 2065 (ChemIDplus), Phthalic acid, diisononyl ester (ChemIDplus)
IUPAC bis(7-methyloctyl) benzene-1,2-dicarboxylate
Formula C26H42O4
PRIMARY ID
(Read more)		 CHEBI:35459
Type chemical
Relations 3

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Type: Score: Layout: SPV 
0.80.80.8diisononyl phthalateNR1I2monoisononyl phthalateOXER1

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Relations
Regulator
Mechanism
target
score ℹ
+ diisononyl phthalateup-regulates activity img/direct-activation.png chemical activation NR1I2 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-268775 Chlorocebus aethiops COS-1 Cell
pmid sentence
We discovered that di(2-ethylhexyl) phthalate (DEHP) and di-isononyl phthalate (DiNP), two of the highest volume production agents, were potent activators of human CAR2 (hCAR2), a unique human CAR splice variant and, to a lesser degree, human PXR (hPXR).
Publications: 1 Organism: Chlorocebus Aethiops
+ diisononyl phthalateup-regulates quantity img/direct-activation.png precursor of monoisononyl phthalate 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-268771 in vitro
pmid sentence
The primary metabolite of DiNP is monoisononyl-phthalate (MiNP) and the secondary metabolites include three oxidative derivatives of DiNP, which have been identified mainly in urine: mono-oxoisononyl phthalate (MOINP or oxo-MiNP), mono-carboxyisooctyl phthalate (MCIOP, MCOP or cx-MiNP), and mono-hydroxyisononyl phthalate (MHINP or OH-MiNP).
Publications: 1 Organism: In Vitro
+ diisononyl phthalateup-regulates activity img/direct-activation.png chemical activation OXER1 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-268773 Chlorocebus aethiops COS-1 Cell
pmid sentence
We discovered that di(2-ethylhexyl) phthalate (DEHP) and di-isononyl phthalate (DiNP), two of the highest volume production agents, were potent activators of human CAR2 (hCAR2), a unique human CAR splice variant and, to a lesser degree, human PXR (hPXR).
Publications: 1 Organism: Chlorocebus Aethiops
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