3.0
Summary
| Name |  NR1I2View Modifications |
| Full Name | Nuclear receptor subfamily 1 group I member 2 |
| Synonyms | Orphan nuclear receptor PAR1, Orphan nuclear receptor PXR, Pregnane X receptor, Steroid and xenobiotic receptor, SXR | PXR |
| Primary ID | O75469 |
| Links |  -  -  |
| Type | protein |
| Relations | 16 |
| Function | Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CDK2 | down-regulates quantity by destabilization 
phosphorylation
|
NR1I2 | 0.372 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | phenobarbital | up-regulates activity 
chemical activation
|
NR1I2 | 0.8 |
| Publications: | 1 | Organism: | Chlorocebus Aethiops | |
| + | NR1I2 | up-regulates quantity by expression 
transcriptional regulation
|
ABCB1 | 0.457 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NR1I2 | up-regulates quantity by expression
transcriptional regulation
|
UGT1A1 | 0.454 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | lovastatin | up-regulates activity
chemical activation
|
NR1I2 | 0.8 |
| Publications: | 1 | Organism: | Chlorocebus Aethiops | |
| + | bis(2-ethylhexyl) phthalate | up-regulates activity
chemical activation
|
NR1I2 | 0.8 |
| Publications: | 1 | Organism: | Chlorocebus Aethiops | |
| + | monoisononyl phthalate | up-regulates activity
chemical activation
|
NR1I2 | 0.8 |
| Publications: | 1 | Organism: | Chlorocebus Aethiops | |
| + | NR1I2 | up-regulates quantity by expression
transcriptional regulation
|
CYP3A4 | 0.519 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | diisononyl phthalate | up-regulates activity
chemical activation
|
NR1I2 | 0.8 |
| Publications: | 1 | Organism: | Chlorocebus Aethiops | |
| + | NR0B2 | down-regulates
binding
|
NR1I2 | 0.56 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CDK5 | down-regulates activity
phosphorylation
|
NR1I2 | 0.344 |
| Publications: | 1 | Organism: | In Vitro | |
| + | nifedipine | up-regulates activity
chemical activation
|
NR1I2 | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NR1I2 | up-regulates
binding
|
RXRA | 0.534 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | mono(2-ethylhexyl) phthalate | up-regulates activity
chemical activation
|
NR1I2 | 0.8 |
| Publications: | 1 | Organism: | Chlorocebus Aethiops | |
| + | clotrimazole | up-regulates activity
chemical activation
|
NR1I2 | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | mifepristone | up-regulates activity
chemical activation
|
NR1I2 | 0.8 |
| Publications: | 1 | Organism: | Chlorocebus Aethiops | |