| + |
NR0B2 | down-regulates 
binding
|
NR1I2 |
0.578 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-101924 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12805410 |
Our results suggest that shp is a negative regulator of pxr transcriptional activity. This conclusion derives from_ in vitro, cell culture, and_ in vivo_ experiments. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
phenobarbital | up-regulates activity 
chemical activation
|
NR1I2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258830 |
|
|
Chlorocebus aethiops |
CV-1 Cell |
| pmid |
sentence |
| 9727070 |
The antihypercholesterolemic drug lovastatin also activated hPXR as did phenobarbital and the organochlorine pesticide transnonachlor (Fig. 4 A). Thus, hPXR is activated by a remarkably diverse group of synthetic compounds that are known to induce CYP3A4 gene expression (Fig. 4 C). |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
clotrimazole | up-regulates activity
chemical activation
|
NR1I2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259065 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9770465 |
In addition to rifampicin, other known inducers of human CYP3A4 expression, including nifedipine and clotrimazole, also activated hPAR. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NR1I2 | up-regulates quantity by expression 
transcriptional regulation
|
ABCB1 |
0.472 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254834 |
|
|
Homo sapiens |
Intestinal Cell Line |
| pmid |
sentence |
| 18540626 |
Among approximately 40 kinds of phytochemicals, tangeretin and ginkgolides A and B markedly induced the PXR-dependent transcriptional activity and also the activity of the human MDR1 promoter. The expression levels of MDR1 mRNA as well as of CYP3A4 mRNA, another gene regulated by PXR, were significantly increased by these phytochemicals. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
nifedipine | up-regulates activity
chemical activation
|
NR1I2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259066 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9770465 |
In addition to rifampicin, other known inducers of human CYP3A4 expression, including nifedipine and clotrimazole, also activated hPAR. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NR1I2 | up-regulates
binding
|
RXRA |
0.546 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-111624 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11706036 |
The constitutive androstane receptor (car, nr1i4), like fxr and pxr, binds dna as a heterodimer with rxr? |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
diisononyl phthalate | up-regulates activity
chemical activation
|
NR1I2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268775 |
|
|
Chlorocebus aethiops |
COS-1 Cell |
| pmid |
sentence |
| 27551952 |
We discovered that di(2-ethylhexyl) phthalate (DEHP) and di-isononyl phthalate (DiNP), two of the highest volume production agents, were potent activators of human CAR2 (hCAR2), a unique human CAR splice variant and, to a lesser degree, human PXR (hPXR). |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
mono(2-ethylhexyl) phthalate | up-regulates activity
chemical activation
|
NR1I2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268777 |
|
|
Chlorocebus aethiops |
COS-1 Cell |
| pmid |
sentence |
| 27551952 |
MEHP and MiNP exhibit potent activation of hCAR2 and hPXR with higher affinities for these receptors than for the hPPARs. The rank order potency for MEHP and MiNP was hCAR2 > hPXR > hPPARs. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
monoisononyl phthalate | up-regulates activity
chemical activation
|
NR1I2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268779 |
|
|
Chlorocebus aethiops |
COS-1 Cell |
| pmid |
sentence |
| 27551952 |
MEHP and MiNP exhibit potent activation of hCAR2 and hPXR with higher affinities for these receptors than for the hPPARs. The rank order potency for MEHP and MiNP was hCAR2 > hPXR > hPPARs. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
NR1I2 | up-regulates quantity by expression
transcriptional regulation
|
UGT1A1 |
0.469 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254440 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18172616 |
This study indicates that hepatocyte nuclear factor 1alpha (HNF1alpha) bound to the proximal promoter motif not only enhances the basal reporter activity of UGT1A1, including the distal (-3570/-3180) and proximal (-165/-1) regions, but also influences the transcriptional regulation of UGT1A1 by CAR, PXR, GR, and AhR to markedly enhance reporter activities. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
mifepristone | up-regulates activity
chemical activation
|
NR1I2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258829 |
|
|
Chlorocebus aethiops |
CV-1 Cell |
| pmid |
sentence |
| 9727070 |
As shown in Fig. 4 A, hPXR was activated by the synthetic steroids dexamethasone, dexamethasone-t-butylacetate, PCN, RU486, spironolactone, and cyproterone-acetate. Dexamethasone-t-butylacetate and RU486 were the most efficacious activators of hPXR among the synthetic steroids tested. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
NR1I2 | up-regulates quantity by expression
transcriptional regulation
|
CYP3A4 |
0.537 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254835 |
|
|
Homo sapiens |
Intestinal Cell Line |
| pmid |
sentence |
| 18540626 |
Among approximately 40 kinds of phytochemicals, tangeretin and ginkgolides A and B markedly induced the PXR-dependent transcriptional activity and also the activity of the human MDR1 promoter. The expression levels of MDR1 mRNA as well as of CYP3A4 mRNA, another gene regulated by PXR, were significantly increased by these phytochemicals. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
lovastatin | up-regulates activity
chemical activation
|
NR1I2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258828 |
|
|
Chlorocebus aethiops |
CV-1 Cell |
| pmid |
sentence |
| 9727070 |
The antihypercholesterolemic drug lovastatin also activated hPXR as did phenobarbital and the organochlorine pesticide transnonachlor (Fig. 4 A). Thus, hPXR is activated by a remarkably diverse group of synthetic compounds that are known to induce CYP3A4 gene expression (Fig. 4 C). |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
bis(2-ethylhexyl) phthalate | up-regulates activity
chemical activation
|
NR1I2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268774 |
|
|
Chlorocebus aethiops |
COS-1 Cell |
| pmid |
sentence |
| 27551952 |
We discovered that di(2-ethylhexyl) phthalate (DEHP) and di-isononyl phthalate (DiNP), two of the highest volume production agents, were potent activators of human CAR2 (hCAR2), a unique human CAR splice variant and, to a lesser degree, human PXR (hPXR). |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
3.0
NR1I2
- 
- 