| + |
perfluorooctanoic acid | up-regulates activity 
chemical activation
|
PPARA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268790 |
|
|
Mus musculus |
3T3-L1 Cell |
| pmid |
sentence |
| 16731579 |
Human, mouse, and rat PPARα were activated by PFOA isomers and PFOS. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268753 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 35370244 |
Detailed in vitro studies on the effects of perfluorooctanoic acid (PFOA) have demonstrated that activation of peroxisome proliferator-activated receptor α (PPARα) is a key process by which PFOA affects the malignancy of estrogen receptor α (ERα)-positive breast cancer cells. |
|
| Publications: |
2 |
Organism: |
Mus Musculus, Homo Sapiens |
| + |
perfluorooctanoic acid | down-regulates activity 
chemical inhibition
|
AR |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268768 |
|
|
in vitro |
|
| pmid |
sentence |
| 23764977 |
Seven PFCs [perfluorohexane sulfonate (PFHxS), perfluorooctane sulfonate (PFOS), perfluorooctanoate (PFOA), perfluorononanoate (PFNA), perfluorodecanoate (PFDA), perfluoroundecanoate (PFUnA), and perfluorododecanoate (PFDoA)] were analyzed in vitro for their potential to affect estrogen receptor (ER) and androgen receptor (AR) transactivity as well as aromatase enzyme activity. The PFCs were assessed as single compounds and in an equimolar mixture. PFHxS, PFOS and PFOA significantly induced the ER transactivity, whereas PFHxS, PFOS, PFOA, PFNA and PFDA significantly antagonized the AR activity in a concentration-dependent manner. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
perfluorooctanoic acid | up-regulates activity
chemical activation
|
ESR2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268765 |
|
|
in vitro |
|
| pmid |
sentence |
| 23764977 |
Seven PFCs [perfluorohexane sulfonate (PFHxS), perfluorooctane sulfonate (PFOS), perfluorooctanoate (PFOA), perfluorononanoate (PFNA), perfluorodecanoate (PFDA), perfluoroundecanoate (PFUnA), and perfluorododecanoate (PFDoA)] were analyzed in vitro for their potential to affect estrogen receptor (ER) and androgen receptor (AR) transactivity as well as aromatase enzyme activity. The PFCs were assessed as single compounds and in an equimolar mixture. PFHxS, PFOS and PFOA significantly induced the ER transactivity, whereas PFHxS, PFOS, PFOA, PFNA and PFDA significantly antagonized the AR activity in a concentration-dependent manner. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
perfluorooctanoic acid | up-regulates activity
chemical activation
|
PPARG |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268788 |
|
|
Mus musculus |
3T3-L1 Cell |
| pmid |
sentence |
| 16731579 |
Taken together, these data show that of the NRs studied, PPARα is the most likely target of PFOA and PFOS, although PPARγ is also activated to some extent. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
perfluorooctanoic acid | up-regulates activity
chemical activation
|
ESR1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268762 |
|
|
in vitro |
|
| pmid |
sentence |
| 23764977 |
Seven PFCs [perfluorohexane sulfonate (PFHxS), perfluorooctane sulfonate (PFOS), perfluorooctanoate (PFOA), perfluorononanoate (PFNA), perfluorodecanoate (PFDA), perfluoroundecanoate (PFUnA), and perfluorododecanoate (PFDoA)] were analyzed in vitro for their potential to affect estrogen receptor (ER) and androgen receptor (AR) transactivity as well as aromatase enzyme activity. The PFCs were assessed as single compounds and in an equimolar mixture. PFHxS, PFOS and PFOA significantly induced the ER transactivity, whereas PFHxS, PFOS, PFOA, PFNA and PFDA significantly antagonized the AR activity in a concentration-dependent manner. |
|
| Publications: |
1 |
Organism: |
In Vitro |
3.0
perfluorooctanoic acid
