+ |
estramustine | up-regulates activity
chemical activation
|
ESR2 |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-259299 |
|
|
Homo sapiens |
|
pmid |
sentence |
14755680 |
A variety of new estrogenic/anti‐estrogenic/selective estrogen receptor modulator (SERM)‐like compounds, including 2‐methoxyestradiol, genistein, resveratrol, licochalcone, Raloxifene, ICI 182,780, and estramustine are being evaluated for their potential in the next generation of PCa therapies. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
estramustine | down-regulates activity
chemical inhibition
|
MAP2 |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-259298 |
|
|
in vitro |
|
pmid |
sentence |
1647395 |
Estramustine is a novel anti-microtubule drug shown to bind MAP-1 and MAP-2 (microtubule-associated proteins) in vitro. In this paper we have shown that estramustine specifically binds MAP-1A in Du 145a cells, resulting in disruption of MAP-1A microtubules and inhibition of type IV collagenase secretion. |
|
Publications: |
1 |
Organism: |
In Vitro |
+ |
estramustine | down-regulates activity
chemical inhibition
|
MAP1A |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-259297 |
|
|
Homo sapiens |
DU-145 Cell |
pmid |
sentence |
1647395 |
Estramustine is a novel anti-microtubule drug shown to bind MAP-1 and MAP-2 (microtubule-associated proteins) in vitro. In this paper we have shown that estramustine specifically binds MAP-1A in Du 145a cells, resulting in disruption of MAP-1A microtubules and inhibition of type IV collagenase secretion. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
estramustine | up-regulates activity
chemical activation
|
ESR1 |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-259296 |
|
|
Homo sapiens |
|
pmid |
sentence |
14755680 |
A variety of new estrogenic/anti‐estrogenic/selective estrogen receptor modulator (SERM)‐like compounds, including 2‐methoxyestradiol, genistein, resveratrol, licochalcone, Raloxifene, ICI 182,780, and estramustine are being evaluated for their potential in the next generation of PCa therapies. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |