| + |
MARK1 | down-regulates activity 
phosphorylation
|
MAP2 |
0.428 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250163 |
Ser1540 |
KSPEKRSsLPRPSSI |
in vitro |
|
| pmid |
sentence |
| 8631898 |
Here we show that p110mark phosphorylates analogous KXGS sites in the microtubule binding domains of the neuronal MAP2 and the ubiquitous MAP4. Phosphorylation in vitro leads to the dissociation of MAP2 and MAP4 from microtubules and to a pronounced increase in dynamic instability. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250164 |
Ser1679 |
NVKSKIGsTDNIKYQ |
in vitro |
|
| pmid |
sentence |
| 8631898 |
Here we show that p110mark phosphorylates analogous KXGS sites in the microtubule binding domains of the neuronal MAP2 and the ubiquitous MAP4. Phosphorylation in vitro leads to the dissociation of MAP2 and MAP4 from microtubules and to a pronounced increase in dynamic instability. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250165 |
Ser1710 |
HVTSKCGsLKNIRHR |
in vitro |
|
| pmid |
sentence |
| 8631898 |
Here we show that p110mark phosphorylates analogous KXGS sites in the microtubule binding domains of the neuronal MAP2 and the ubiquitous MAP4. Phosphorylation in vitro leads to the dissociation of MAP2 and MAP4 from microtubules and to a pronounced increase in dynamic instability. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250166 |
Ser1795 |
VASPRRLsNVSSSGS |
in vitro |
|
| pmid |
sentence |
| 8631898 |
Here we show that p110mark phosphorylates analogous KXGS sites in the microtubule binding domains of the neuronal MAP2 and the ubiquitous MAP4. Phosphorylation in vitro leads to the dissociation of MAP2 and MAP4 from microtubules and to a pronounced increase in dynamic instability. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250167 |
Ser1799 |
RRLSNVSsSGSINLL |
in vitro |
|
| pmid |
sentence |
| 8631898 |
Here we show that p110mark phosphorylates analogous KXGS sites in the microtubule binding domains of the neuronal MAP2 and the ubiquitous MAP4. Phosphorylation in vitro leads to the dissociation of MAP2 and MAP4 from microtubules and to a pronounced increase in dynamic instability. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250168 |
Ser1802 |
SNVSSSGsINLLESP |
in vitro |
|
| pmid |
sentence |
| 8631898 |
Here we show that p110mark phosphorylates analogous KXGS sites in the microtubule binding domains of the neuronal MAP2 and the ubiquitous MAP4. Phosphorylation in vitro leads to the dissociation of MAP2 and MAP4 from microtubules and to a pronounced increase in dynamic instability. |
|
| Publications: |
6 |
Organism: |
In Vitro |
| + |
PRKACA | down-regulates activity
phosphorylation
|
MAP2 |
0.366 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250001 |
Ser1679 |
NVKSKIGsTDNIKYQ |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11029056 |
CAMP-dependent protein kinase activity disrupts the MAP2-microtubule interaction in living HeLa cells. S319, S350, and S382 were thus identified as preferred targets of PKA |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250002 |
Ser1710 |
HVTSKCGsLKNIRHR |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11029056 |
CAMP-dependent protein kinase activity disrupts the MAP2-microtubule interaction in living HeLa cells. S319, S350, and S382 were thus identified as preferred targets of PKA |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250003 |
Ser1742 |
KAQAKVGsLDNAHHV |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11029056 |
CAMP-dependent protein kinase activity disrupts the MAP2-microtubule interaction in living HeLa cells. S319, S350, and S382 were thus identified as preferred targets of PKA |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
PRKACA | up-regulates 
phosphorylation
|
MAP2 |
0.366 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-83100 |
Ser1782 |
GAEIITQsPGRSSVA |
Homo sapiens |
HeLa Cell, Neuron |
| pmid |
sentence |
| 11029056 |
Specific phosphorylation states may enhance the interaction of map2 with the actin cytoskeleton, thereby providing a regulated mechanism for map2 function within distinct cytoskeletal domains |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain |
| + |
CHD8 | down-regulates quantity
transcriptional regulation
|
MAP2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268916 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 32839322 |
Many of the most significantly up-regulated genes in Chd8+/− and Chd8−/− NPCs are involved in later stages of neuronal development, including Ascl1 [a central driver of neural reprogramming (29)], Dcx, Map2, Nefm, Neurod4, and Neurog1 (Fig. 2 E and F). Additionally, we found that Sox3 is derepressed in both Chd8+/− and Chd8−/− NPCs, and several other Sox TF members (Sox2, Sox7, and Sox11) became derepressed in the Chd8−/− cells |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
MAP2 | up-regulates quantity by stabilization
binding
|
Microtubule_polimerization |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264837 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 10704996 |
MAP2 interacts with MTs through its tubulin-binding domain which mainly associates with the acidic region of the C-terminal region of tubulin|no neurite growth is observed when MAP2 expression is suppressed in neuronal cell cultures after treatment with specific antisense oligonucleotides |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
estramustine | down-regulates activity
chemical inhibition
|
MAP2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259298 |
|
|
in vitro |
|
| pmid |
sentence |
| 1647395 |
Estramustine is a novel anti-microtubule drug shown to bind MAP-1 and MAP-2 (microtubule-associated proteins) in vitro. In this paper we have shown that estramustine specifically binds MAP-1A in Du 145a cells, resulting in disruption of MAP-1A microtubules and inhibition of type IV collagenase secretion. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
DPYSL5 | down-regulates activity
binding
|
MAP2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264836 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 25040932 |
The studies on CRMP5 function show that, by interacting with tubulin and MAP2, this protein inhibits neurite growth especially at the dendritic level and restricts the promotional effect of CRMP2 on axon and dendrite growth |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
MAP2
- 
- 