| + |
HADH | up-regulates quantity 
chemical modification
|
acetoacetyl-CoA(4-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280424 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16176262 |
3-Hydroxyacyl-CoA dehydrogenase (HAD) functions in mitochondrial fatty acid beta-oxidation by catalyzing the oxidation of straight chain 3-hydroxyacyl-CoAs. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
(S)-3-hydroxybutanoyl-CoA | up-regulates quantity
precursor of
|
acetoacetyl-CoA(4-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280425 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16176262 |
3-Hydroxyacyl-CoA dehydrogenase (HAD) functions in mitochondrial fatty acid beta-oxidation by catalyzing the oxidation of straight chain 3-hydroxyacyl-CoAs. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ACAT1 | down-regulates quantity 
chemical modification
|
acetoacetyl-CoA(4-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280426 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31268215 |
The mitochondrial acetoacetyl‐CoA thiolase (commonly known as β‐ketothiolase [T2]; EC 2.3.1.9; encoded by the ACAT1 gene) is a ubiquitous and important enzyme for ketone body synthesis and degradation as well as in isoleucine catabolismIn the biosynthetic direction, thiolases catalyze the formation of a carbon‐carbon bond through a Claisen condensation mechanism (from two acetyl‐CoA molecules) and in the reverse, degradative direction a C‐C bond is broken through thiolysis (in the presence of CoA), resulting in chain shortening of the acyl chain by two carbon atoms (in case the substrate is an unbranched acyl chain) or by three atoms (in case the substrate is a 2‐methyl‐branched acyl chain), such as for example catalyzed by the T2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ACAT1 | up-regulates quantity
precursor of
|
acetoacetyl-CoA(4-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280431 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31268215 |
The mitochondrial acetoacetyl‐CoA thiolase (commonly known as β‐ketothiolase [T2]; EC 2.3.1.9; encoded by the ACAT1 gene) is a ubiquitous and important enzyme for ketone body synthesis and degradation as well as in isoleucine catabolismIn the biosynthetic direction, thiolases catalyze the formation of a carbon‐carbon bond through a Claisen condensation mechanism (from two acetyl‐CoA molecules) and in the reverse, degradative direction a C‐C bond is broken through thiolysis (in the presence of CoA), resulting in chain shortening of the acyl chain by two carbon atoms (in case the substrate is an unbranched acyl chain) or by three atoms (in case the substrate is a 2‐methyl‐branched acyl chain), such as for example catalyzed by the T2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
acetoacetyl-CoA(4-) | up-regulates quantity
precursor of
|
acetyl-CoA(4-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280428 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31268215 |
The mitochondrial acetoacetyl‐CoA thiolase (commonly known as β‐ketothiolase [T2]; EC 2.3.1.9; encoded by the ACAT1 gene) is a ubiquitous and important enzyme for ketone body synthesis and degradation as well as in isoleucine catabolismIn the biosynthetic direction, thiolases catalyze the formation of a carbon‐carbon bond through a Claisen condensation mechanism (from two acetyl‐CoA molecules) and in the reverse, degradative direction a C‐C bond is broken through thiolysis (in the presence of CoA), resulting in chain shortening of the acyl chain by two carbon atoms (in case the substrate is an unbranched acyl chain) or by three atoms (in case the substrate is a 2‐methyl‐branched acyl chain), such as for example catalyzed by the T2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
acetoacetyl-CoA(4-)