Summary

Name HADH
Full Name Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
Synonyms HCDH, Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase, Short-chain 3-hydroxyacyl-CoA dehydrogenase | HAD, HADHSC, SCHAD
Primary ID Q16836
Links - -
Type protein
Relations 12
Pathways Fatty Acid Beta-Oxidation
Function Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10) (PubMed:10231530, PubMed:11489939, PubMed:16725361). Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion (By similarity).

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Relations

Regulator Mechanism target score ℹ
+ HADHdown-regulates quantity img/direct_inhibition.png chemical modification (S)-3-hydroxylauroyl-CoA 0.2
Publications: 1 Organism: Homo Sapiens
+ HADHup-regulates quantity img/direct-activation.png chemical modification 3-oxolauroyl-CoA 0.8
Publications: 1 Organism: Homo Sapiens
+ HADHup-regulates quantity img/direct-activation.png chemical modification NADH(2-) 0.8
Publications: 1 Organism: Homo Sapiens
+ HADHdown-regulates quantity img/direct_inhibition.png chemical modification (S)-3-hydroxydecanoyl-CoA 0.8
Publications: 1 Organism: Homo Sapiens
+ HADHup-regulates quantity img/direct-activation.png chemical modification 3-oxodecanoyl-CoA 0.8
Publications: 1 Organism: Homo Sapiens
+ HADHdown-regulates quantity img/direct_inhibition.png chemical modification (S)-3-hydroxyhexanoyl-CoA 0.8
Publications: 1 Organism: Homo Sapiens
+ HADHup-regulates quantity img/direct-activation.png chemical modification 3-oxohexanoyl-CoA 0.8
Publications: 1 Organism: Homo Sapiens
+ HADHup-regulates quantity img/direct-activation.png chemical modification acetoacetyl-CoA(4-) 0.8
Publications: 1 Organism: Homo Sapiens
+ HADHdown-regulates quantity img/direct_inhibition.png chemical modification NAD(1-) 0.8
Publications: 1 Organism: Homo Sapiens
+ HADHup-regulates quantity img/direct-activation.png chemical modification 3-oxooctanoyl-CoA 0.8
Publications: 1 Organism: Homo Sapiens
+ HADHdown-regulates quantity img/direct_inhibition.png chemical modification (S)-3-hydroxyoctanoyl-CoA 0.8
Publications: 1 Organism: Homo Sapiens
+ HADHdown-regulates quantity img/direct_inhibition.png chemical modification (S)-3-hydroxybutanoyl-CoA 0.8
Publications: 1 Organism: Homo Sapiens