3.0
Summary
| Name |  ACAT1View Modifications |
| Full Name | Acetyl-CoA acetyltransferase, mitochondrial |
| Synonyms | Acetoacetyl-CoA thiolase, T2 | ACAT, MAT |
| Primary ID | P24752 |
| Links |  -  -  |
| Type | protein |
| Relations | 7 |
| Function | This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA (PubMed:1715688, PubMed:7728148, PubMed:9744475). Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms (PubMed:1715688, PubMed:7728148, PubMed:9744475). The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA (PubMed:17371050). Thereby, it plays a major role in ketone body metabolism (PubMed:17371050, PubMed:1715688, PubMed:7728148, PubMed:9744475). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | ACAT1 | up-regulates activity 
acetylation
|
ME1 | 0.251 |
| Publications: | 1 | |||
| + | ACAT1 | down-regulates activity 
acetylation
|
IDH2 | 0.291 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | FGFR1 | up-regulates activity
phosphorylation
|
ACAT1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | FLT3 | up-regulates activity
phosphorylation
|
ACAT1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ACAT1 | down-regulates activity
acetylation
|
PDHA2 | 0.2 |
| Publications: | 1 | |||
| + | ACAT1 | down-regulates activity
acetylation
|
PDHA1 | 0.402 |
| Publications: | 1 | |||
| + | ACAT1 | down-regulates activity
acetylation
|
PDP1 | 0.346 |
| Publications: | 1 | |||