| + |
DHFR2 | down-regulates quantity 
chemical modification
|
dihydrofolate(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268260 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21876184 |
Human dihydrofolate reductase (DHFR) was previously thought to be the only enzyme capable of the reduction of dihydrofolate to tetrahydrofolate; an essential reaction necessary to ensure a continuous supply of biologically active folate. |We demonstrate that the DHFRP4, or dihydrofolate reductase-like 1 (DHFRL1), gene is expressed and shares some commonalities with DHFR. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TYMS | up-regulates quantity 
chemical modification
|
dihydrofolate(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268232 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21876188 |
In this pathway, 5,10-methyleneTHF, a one-carbon donor, is generated from serine by SHMT and used for the conversion of dUMP to dTMP in a reaction catalyzed by TYMS. The TYMS-catalyzed reaction generates dihydrofolate, which is converted to THF in an NADPH-dependent manner by DHFR. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | One-carbon Metabolism |
| + |
dihydrofolate(2-) | up-regulates quantity
precursor of
|
(6S)-5,6,7,8-tetrahydrofolate(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268259 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21876184 |
Human dihydrofolate reductase (DHFR) was previously thought to be the only enzyme capable of the reduction of dihydrofolate to tetrahydrofolate; an essential reaction necessary to ensure a continuous supply of biologically active folate. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | One-carbon Metabolism |
| + |
SLC46A1 | up-regulates quantity
relocalization
|
dihydrofolate(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268264 |
|
|
Homo sapiens |
Hepatocyte |
| pmid |
sentence |
| 17129779 |
However, the current study establishes that a major function of this gene product is proton-coupled folate transport required for folate homeostasis in man, and we have thus amended the name to PCFT/HCP1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
folic acid | up-regulates quantity
precursor of
|
dihydrofolate(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268263 |
|
|
Homo sapiens |
Hepatocyte |
| pmid |
sentence |
| 19706381 |
However, since the synthesis of folic acid (FA, pteroylglutamic acid) as a provitamin in 1945, DHFR has taken on another role: reduction of FA to 7,8-DHF (Fig. 1) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | One-carbon Metabolism |
| + |
(6R)-5,10-methylenetetrahydrofolate(2-) | up-regulates quantity
precursor of
|
dihydrofolate(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268233 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21876188 |
In this pathway, 5,10-methyleneTHF, a one-carbon donor, is generated from serine by SHMT and used for the conversion of dUMP to dTMP in a reaction catalyzed by TYMS. The TYMS-catalyzed reaction generates dihydrofolate, which is converted to THF in an NADPH-dependent manner by DHFR. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | One-carbon Metabolism |
| + |
DHFR | down-regulates quantity
chemical modification
|
dihydrofolate(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268257 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21876184 |
Human dihydrofolate reductase (DHFR) was previously thought to be the only enzyme capable of the reduction of dihydrofolate to tetrahydrofolate; an essential reaction necessary to ensure a continuous supply of biologically active folate. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | One-carbon Metabolism |
3.0
dihydrofolate(2-)