| + |
precursor messenger RNA | up-regulates quantity 
precursor of
|
messenger RNA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268314 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19224921 |
Because only mRNA molecules that have been correctly spliced, capped at the 5′ extremity, and processed at the 3′ extremity can be used as templates for translation, processing of mRNA precursors plays a critical role in the regulation of gene expression. 3′ processing of pre-mRNAs comprises two steps (reviewed in Ref. 4): cleavage and polyadenylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | mRNA maturation, mRNA maturation |
| + |
RNA Polymerase II | up-regulates quantity
chemical modification
|
precursor messenger RNA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266176 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22260999 |
In eukaryotic cells, the RNA polymerase Pol I synthesizes the rRNA precursor, Pol II transcribes mRNAs and small non-coding RNAs (such as small nuclear RNAs), and Pol III produces tRNAs and other small RNAs. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | mRNA maturation, mRNA maturation, Transcription initiation |
| + |
precursor messenger RNA | up-regulates activity
relocalization
|
SF3b |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268413 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32140746 |
The SF3b complex is an intrinsic component of the functional U2 small nuclear ribonucleoprotein (snRNP). As U2 snRNP enters nuclear pre-mRNA splicing, SF3b plays key roles in recognizing the branch point sequence (BPS) and facilitating spliceosome assembly and activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
precursor messenger RNA