| + |
NELF | down-regulates activity 
binding
|
RNA Polymerase II |
0.428 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271403 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18628398 |
The Negative Elongation Factor (NELF) is a transcription regulatory complex that induces stalling of RNA polymerase II (Pol II) during early transcription elongation and represses expression of several genes studied to date, including Drosophila Hsp70, mammalian proto-oncogene junB, and HIV RNA. It is composed of four subunits, NELF-A, NELF-B, NELF-C/D, and NELF-E. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
POLR2M | form complex 
binding
|
RNA Polymerase II |
0.44 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266175 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 9852112 |
Pol II is composed of 10–12 polypeptides ranging in size from 220 to 7 kDa, depending on the source of purification (11, 12, 13). The subunits of human pol II (or RNA polymerase B) have been defined as RPB1 (220 kDa), RPB2 (140 kDa), RPB3 (33 kDa), RPB4 (18 kDa), RPB5 (28 kDa), RPB6 (19 kDa), RPB7 (27 kDa), RPB8 (17 kDa), RPB9 (14.5 kDa), RPB10alpha (or RPB12, 7.0 kDa), RPB10beta (or RPB10, 7.6 kDa), and RPB11 (14 kDa) (3,11, 12, 13). RPB5, RPB6, RPB8, RPB10alpha, and RPB10beta are shared by all three eukaryotic RNA polymerases, whereas the rest of the RPB components are unique to pol II |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
POLR2J | form complex
binding
|
RNA Polymerase II |
0.823 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266161 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 9852112 |
Pol II is composed of 10–12 polypeptides ranging in size from 220 to 7 kDa, depending on the source of purification (11, 12, 13). The subunits of human pol II (or RNA polymerase B) have been defined as RPB1 (220 kDa), RPB2 (140 kDa), RPB3 (33 kDa), RPB4 (18 kDa), RPB5 (28 kDa), RPB6 (19 kDa), RPB7 (27 kDa), RPB8 (17 kDa), RPB9 (14.5 kDa), RPB10alpha (or RPB12, 7.0 kDa), RPB10beta (or RPB10, 7.6 kDa), and RPB11 (14 kDa) (3,11, 12, 13). RPB5, RPB6, RPB8, RPB10alpha, and RPB10beta are shared by all three eukaryotic RNA polymerases, whereas the rest of the RPB components are unique to pol II |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
POLR2F | form complex
binding
|
RNA Polymerase II |
0.871 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266170 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 9852112 |
Pol II is composed of 10–12 polypeptides ranging in size from 220 to 7 kDa, depending on the source of purification (11, 12, 13). The subunits of human pol II (or RNA polymerase B) have been defined as RPB1 (220 kDa), RPB2 (140 kDa), RPB3 (33 kDa), RPB4 (18 kDa), RPB5 (28 kDa), RPB6 (19 kDa), RPB7 (27 kDa), RPB8 (17 kDa), RPB9 (14.5 kDa), RPB10alpha (or RPB12, 7.0 kDa), RPB10beta (or RPB10, 7.6 kDa), and RPB11 (14 kDa) (3,11, 12, 13). RPB5, RPB6, RPB8, RPB10alpha, and RPB10beta are shared by all three eukaryotic RNA polymerases, whereas the rest of the RPB components are unique to pol II |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Core mediator complex | up-regulates activity 
binding
|
RNA Polymerase II |
0.329 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266682 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25693131 |
The RNA polymerase II (Pol II) enzyme transcribes all protein-coding and most non-coding RNA genes and is globally regulated by Mediator — a large, conformationally flexible protein complex with a variable subunit composition (for example, a four-subunit cyclin-dependent kinase 8 module can reversibly associate with it). Because of its direct and extensive interactions with Pol II, Mediator regulates multiple stages of Pol II transcription (for example, initiation and re-initiation). Mediator interactions with the super elongation complex (SEC) also seem to be important for its regulation of Pol II elongation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Transcription initiation |
| + |
POLR2G | form complex
binding
|
RNA Polymerase II |
0.866 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266165 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 9852112 |
Pol II is composed of 10–12 polypeptides ranging in size from 220 to 7 kDa, depending on the source of purification (11, 12, 13). The subunits of human pol II (or RNA polymerase B) have been defined as RPB1 (220 kDa), RPB2 (140 kDa), RPB3 (33 kDa), RPB4 (18 kDa), RPB5 (28 kDa), RPB6 (19 kDa), RPB7 (27 kDa), RPB8 (17 kDa), RPB9 (14.5 kDa), RPB10alpha (or RPB12, 7.0 kDa), RPB10beta (or RPB10, 7.6 kDa), and RPB11 (14 kDa) (3,11, 12, 13). RPB5, RPB6, RPB8, RPB10alpha, and RPB10beta are shared by all three eukaryotic RNA polymerases, whereas the rest of the RPB components are unique to pol II |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MYH9 | up-regulates activity
binding
|
RNA Polymerase II |
0.252 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269285 |
|
|
Homo sapiens |
MGC-803 Cell |
| pmid |
sentence |
| 32685004 |
Nuclear MYH9 bound to the CTNNB1 promoter through its DNA-binding domain, and interacted with myosin light chain 9, β-actin and RNA polymerase II to promote CTNNB1 transcription, which conferred resistance to anoikis in GC cells in vitro and in vivo. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
POLR2I | form complex
binding
|
RNA Polymerase II |
0.846 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266166 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 9852112 |
Pol II is composed of 10–12 polypeptides ranging in size from 220 to 7 kDa, depending on the source of purification (11, 12, 13). The subunits of human pol II (or RNA polymerase B) have been defined as RPB1 (220 kDa), RPB2 (140 kDa), RPB3 (33 kDa), RPB4 (18 kDa), RPB5 (28 kDa), RPB6 (19 kDa), RPB7 (27 kDa), RPB8 (17 kDa), RPB9 (14.5 kDa), RPB10alpha (or RPB12, 7.0 kDa), RPB10beta (or RPB10, 7.6 kDa), and RPB11 (14 kDa) (3,11, 12, 13). RPB5, RPB6, RPB8, RPB10alpha, and RPB10beta are shared by all three eukaryotic RNA polymerases, whereas the rest of the RPB components are unique to pol II |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
POLR2M | form complex
binding
|
RNA Polymerase II |
0.44 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266169 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9852112 |
Pol II is composed of 10–12 polypeptides ranging in size from 220 to 7 kDa, depending on the source of purification (11, 12, 13). The subunits of human pol II (or RNA polymerase B) have been defined as RPB1 (220 kDa), RPB2 (140 kDa), RPB3 (33 kDa), RPB4 (18 kDa), RPB5 (28 kDa), RPB6 (19 kDa), RPB7 (27 kDa), RPB8 (17 kDa), RPB9 (14.5 kDa), RPB10alpha (or RPB12, 7.0 kDa), RPB10beta (or RPB10, 7.6 kDa), and RPB11 (14 kDa) (3,11, 12, 13). RPB5, RPB6, RPB8, RPB10alpha, and RPB10beta are shared by all three eukaryotic RNA polymerases, whereas the rest of the RPB components are unique to pol II |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SNAPC | up-regulates activity
binding
|
RNA Polymerase II |
0.443 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280635 |
|
|
|
|
| pmid |
sentence |
| 36369505 |
In eukaryotes, small nuclear RNAs (snRNAs) function in many fundamental cellular events such as precursor messenger RNA splicing, gene expression regulation, and ribosomal RNA processing. The snRNA activating protein complex (SNAPc) exclusively recognizes the proximal sequence element (PSE) at snRNA promoters and recruits RNA polymerase II or III to initiate transcription. |
|
| Publications: |
1 |
| + |
POLR2E | form complex
binding
|
RNA Polymerase II |
0.885 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266167 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 9852112 |
Pol II is composed of 10–12 polypeptides ranging in size from 220 to 7 kDa, depending on the source of purification (11, 12, 13). The subunits of human pol II (or RNA polymerase B) have been defined as RPB1 (220 kDa), RPB2 (140 kDa), RPB3 (33 kDa), RPB4 (18 kDa), RPB5 (28 kDa), RPB6 (19 kDa), RPB7 (27 kDa), RPB8 (17 kDa), RPB9 (14.5 kDa), RPB10alpha (or RPB12, 7.0 kDa), RPB10beta (or RPB10, 7.6 kDa), and RPB11 (14 kDa) (3,11, 12, 13). RPB5, RPB6, RPB8, RPB10alpha, and RPB10beta are shared by all three eukaryotic RNA polymerases, whereas the rest of the RPB components are unique to pol II |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
POLR2J2 | form complex
binding
|
RNA Polymerase II |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266174 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9852112 |
Pol II is composed of 10–12 polypeptides ranging in size from 220 to 7 kDa, depending on the source of purification (11, 12, 13). The subunits of human pol II (or RNA polymerase B) have been defined as RPB1 (220 kDa), RPB2 (140 kDa), RPB3 (33 kDa), RPB4 (18 kDa), RPB5 (28 kDa), RPB6 (19 kDa), RPB7 (27 kDa), RPB8 (17 kDa), RPB9 (14.5 kDa), RPB10alpha (or RPB12, 7.0 kDa), RPB10beta (or RPB10, 7.6 kDa), and RPB11 (14 kDa) (3,11, 12, 13). RPB5, RPB6, RPB8, RPB10alpha, and RPB10beta are shared by all three eukaryotic RNA polymerases, whereas the rest of the RPB components are unique to pol II |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PAF1C | up-regulates activity
binding
|
RNA Polymerase II |
0.481 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269837 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 20178742 |
HPAF1C Independently and Cooperatively (with SII) Stimulates Transcription Elongation. Direct Interactions of hPAF1C with Pol II and SII Are Required for Its Intrinsic and Synergistic Effects on Chromatin Transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
POLR2C | form complex
binding
|
RNA Polymerase II |
0.875 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266163 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 9852112 |
Pol II is composed of 10–12 polypeptides ranging in size from 220 to 7 kDa, depending on the source of purification (11, 12, 13). The subunits of human pol II (or RNA polymerase B) have been defined as RPB1 (220 kDa), RPB2 (140 kDa), RPB3 (33 kDa), RPB4 (18 kDa), RPB5 (28 kDa), RPB6 (19 kDa), RPB7 (27 kDa), RPB8 (17 kDa), RPB9 (14.5 kDa), RPB10alpha (or RPB12, 7.0 kDa), RPB10beta (or RPB10, 7.6 kDa), and RPB11 (14 kDa) (3,11, 12, 13). RPB5, RPB6, RPB8, RPB10alpha, and RPB10beta are shared by all three eukaryotic RNA polymerases, whereas the rest of the RPB components are unique to pol II |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RNA Polymerase II | up-regulates quantity
chemical modification
|
precursor messenger RNA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266176 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22260999 |
In eukaryotic cells, the RNA polymerase Pol I synthesizes the rRNA precursor, Pol II transcribes mRNAs and small non-coding RNAs (such as small nuclear RNAs), and Pol III produces tRNAs and other small RNAs. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | mRNA maturation, mRNA maturation, Transcription initiation |
| + |
CHD8 | up-regulates activity
binding
|
RNA Polymerase II |
0.273 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268806 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 19255092 |
We also show that CHD8 associates with the elongating form of RNAPII, which is phosphorylated in its carboxy-terminal domain (CTD). Furthermore, CHD8-depleted cells are hypersensitive to drugs that inhibit RNAPII phosphorylation at serine 2, suggesting that CHD8 is required for an early step of the RNAPII transcription cycle. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
POLR2A | form complex
binding
|
RNA Polymerase II |
0.862 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266160 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 9852112 |
Pol II is composed of 10–12 polypeptides ranging in size from 220 to 7 kDa, depending on the source of purification (11, 12, 13). The subunits of human pol II (or RNA polymerase B) have been defined as RPB1 (220 kDa), RPB2 (140 kDa), RPB3 (33 kDa), RPB4 (18 kDa), RPB5 (28 kDa), RPB6 (19 kDa), RPB7 (27 kDa), RPB8 (17 kDa), RPB9 (14.5 kDa), RPB10alpha (or RPB12, 7.0 kDa), RPB10beta (or RPB10, 7.6 kDa), and RPB11 (14 kDa) (3,11, 12, 13). RPB5, RPB6, RPB8, RPB10alpha, and RPB10beta are shared by all three eukaryotic RNA polymerases, whereas the rest of the RPB components are unique to pol II |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Transcription initiation |
| + |
POLR2D | form complex
binding
|
RNA Polymerase II |
0.835 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266164 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 9852112 |
Pol II is composed of 10–12 polypeptides ranging in size from 220 to 7 kDa, depending on the source of purification (11, 12, 13). The subunits of human pol II (or RNA polymerase B) have been defined as RPB1 (220 kDa), RPB2 (140 kDa), RPB3 (33 kDa), RPB4 (18 kDa), RPB5 (28 kDa), RPB6 (19 kDa), RPB7 (27 kDa), RPB8 (17 kDa), RPB9 (14.5 kDa), RPB10alpha (or RPB12, 7.0 kDa), RPB10beta (or RPB10, 7.6 kDa), and RPB11 (14 kDa) (3,11, 12, 13). RPB5, RPB6, RPB8, RPB10alpha, and RPB10beta are shared by all three eukaryotic RNA polymerases, whereas the rest of the RPB components are unique to pol II |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TFIIF | up-regulates activity
relocalization
|
RNA Polymerase II |
0.731 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266199 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18218714 |
Transcription processes in eukaryotes begin with the formation of a pre-initiation complex (PIC), composed of RNA polymerase II (Pol II) associated with five general transcription factors: TFIIB, TFIID, TFIIE, TFIIF, and TFIIH |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Transcription initiation |
| + |
POLR2J3 | form complex
binding
|
RNA Polymerase II |
0.691 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266173 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 9852112 |
Pol II is composed of 10–12 polypeptides ranging in size from 220 to 7 kDa, depending on the source of purification (11, 12, 13). The subunits of human pol II (or RNA polymerase B) have been defined as RPB1 (220 kDa), RPB2 (140 kDa), RPB3 (33 kDa), RPB4 (18 kDa), RPB5 (28 kDa), RPB6 (19 kDa), RPB7 (27 kDa), RPB8 (17 kDa), RPB9 (14.5 kDa), RPB10alpha (or RPB12, 7.0 kDa), RPB10beta (or RPB10, 7.6 kDa), and RPB11 (14 kDa) (3,11, 12, 13). RPB5, RPB6, RPB8, RPB10alpha, and RPB10beta are shared by all three eukaryotic RNA polymerases, whereas the rest of the RPB components are unique to pol II |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
POLR2K | form complex
binding
|
RNA Polymerase II |
0.828 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266168 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 9852112 |
Pol II is composed of 10–12 polypeptides ranging in size from 220 to 7 kDa, depending on the source of purification (11, 12, 13). The subunits of human pol II (or RNA polymerase B) have been defined as RPB1 (220 kDa), RPB2 (140 kDa), RPB3 (33 kDa), RPB4 (18 kDa), RPB5 (28 kDa), RPB6 (19 kDa), RPB7 (27 kDa), RPB8 (17 kDa), RPB9 (14.5 kDa), RPB10alpha (or RPB12, 7.0 kDa), RPB10beta (or RPB10, 7.6 kDa), and RPB11 (14 kDa) (3,11, 12, 13). RPB5, RPB6, RPB8, RPB10alpha, and RPB10beta are shared by all three eukaryotic RNA polymerases, whereas the rest of the RPB components are unique to pol II |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
POLR2H | form complex
binding
|
RNA Polymerase II |
0.821 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266172 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 9852112 |
Pol II is composed of 10–12 polypeptides ranging in size from 220 to 7 kDa, depending on the source of purification (11, 12, 13). The subunits of human pol II (or RNA polymerase B) have been defined as RPB1 (220 kDa), RPB2 (140 kDa), RPB3 (33 kDa), RPB4 (18 kDa), RPB5 (28 kDa), RPB6 (19 kDa), RPB7 (27 kDa), RPB8 (17 kDa), RPB9 (14.5 kDa), RPB10alpha (or RPB12, 7.0 kDa), RPB10beta (or RPB10, 7.6 kDa), and RPB11 (14 kDa) (3,11, 12, 13). RPB5, RPB6, RPB8, RPB10alpha, and RPB10beta are shared by all three eukaryotic RNA polymerases, whereas the rest of the RPB components are unique to pol II |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
POLR2B | form complex
binding
|
RNA Polymerase II |
0.868 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266162 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 9852112 |
Pol II is composed of 10–12 polypeptides ranging in size from 220 to 7 kDa, depending on the source of purification (11, 12, 13). The subunits of human pol II (or RNA polymerase B) have been defined as RPB1 (220 kDa), RPB2 (140 kDa), RPB3 (33 kDa), RPB4 (18 kDa), RPB5 (28 kDa), RPB6 (19 kDa), RPB7 (27 kDa), RPB8 (17 kDa), RPB9 (14.5 kDa), RPB10alpha (or RPB12, 7.0 kDa), RPB10beta (or RPB10, 7.6 kDa), and RPB11 (14 kDa) (3,11, 12, 13). RPB5, RPB6, RPB8, RPB10alpha, and RPB10beta are shared by all three eukaryotic RNA polymerases, whereas the rest of the RPB components are unique to pol II |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
POLR2L | form complex
binding
|
RNA Polymerase II |
0.86 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266171 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 9852112 |
Pol II is composed of 10–12 polypeptides ranging in size from 220 to 7 kDa, depending on the source of purification (11, 12, 13). The subunits of human pol II (or RNA polymerase B) have been defined as RPB1 (220 kDa), RPB2 (140 kDa), RPB3 (33 kDa), RPB4 (18 kDa), RPB5 (28 kDa), RPB6 (19 kDa), RPB7 (27 kDa), RPB8 (17 kDa), RPB9 (14.5 kDa), RPB10alpha (or RPB12, 7.0 kDa), RPB10beta (or RPB10, 7.6 kDa), and RPB11 (14 kDa) (3,11, 12, 13). RPB5, RPB6, RPB8, RPB10alpha, and RPB10beta are shared by all three eukaryotic RNA polymerases, whereas the rest of the RPB components are unique to pol II |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AFF2 | up-regulates activity
binding
|
RNA Polymerase II |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266797 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17135274 |
Here, we provide the first evidence for a direct role of AF4 in the regulation of transcriptional elongation by RNA polymerase II (Pol II). We demonstrate that mouse Af4 functions as a positive regulator of Pol II transcription elongation factor b (P-TEFb) kinase and, in complex with MLL fusion partners Af9, Enl and Af10, as a mediator of histone H3-K79 methylation by recruiting Dot1 to elongating Pol II. These pathways are interconnected and tightly regulated by the P-TEFb-dependent phosphorylation of Af4, Af9 and Enl which controls their transactivation activity and/or protein stability. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TFIIA | up-regulates activity
relocalization
|
RNA Polymerase II |
0.67 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266200 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7724559 |
The human general transcription factor TFIIA is one of several factors involved in specific transcription by RNA polymerase II |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Transcription initiation |
| + |
PHF3 | down-regulates activity
binding
|
RNA Polymerase II |
0.332 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266964 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 34667177 |
PHF3 interacts with RNA polymerase II through the SPOC domain. PHF3 negatively regulates mRNA levels. Here, we identify PHD-finger protein 3 (PHF3) as a regulator of transcription and mRNA stability that docks onto Pol II CTD through its SPOC domain. Our data suggest that PHF3 acts as a prominent effector of neuronal gene regulation by bridging transcription with mRNA decay. PHF3 SPOC preferentially binds RNA Pol II CTD phosphorylated on Serine-2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
RNA Polymerase II
CPX-7481