| + |
EXT1/EXT2 | up-regulates quantity 
chemical modification
|
heparan sulfate octasaccharide |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264016 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20377530 |
HS (heparan sulfate) is synthesized by HS co-polymerases encoded by the EXT1 and EXT2 genes (exostosin 1 and 2), which are known as causative genes for hereditary multiple exostoses, a dominantly inherited genetic disorder characterized by multiple cartilaginous tumours. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
heparan sulfate octasaccharide | up-regulates 
|
ECM_synthesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264017 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27241222 |
Many observations in animal models deficient for HSPGs and recent observations of human genetic mutations for biosynthesis of HSPGs have identified the importance of HSPGs for normal embryonic development and ECM organization. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
heparan sulfate octasaccharide