| + |
EXT1/EXT2 | up-regulates quantity 
chemical modification
|
heparan sulfate octasaccharide |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264016 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20377530 |
HS (heparan sulfate) is synthesized by HS co-polymerases encoded by the EXT1 and EXT2 genes (exostosin 1 and 2), which are known as causative genes for hereditary multiple exostoses, a dominantly inherited genetic disorder characterized by multiple cartilaginous tumours. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EXT1 | form complex 
binding
|
EXT1/EXT2 |
0.563 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-109938 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11518722 |
Biochemical analysis shows that ext1 and ext2 are type ii transmembrane glycoproteins and form a golgi-localized hetero-oligomeric complex that catalyzes the polymerization of hs |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EXT2 | form complex
binding
|
EXT1/EXT2 |
0.563 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-109941 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11518722 |
Biochemical analysis shows that ext1 and ext2 are type ii transmembrane glycoproteins and form a golgi-localized hetero-oligomeric complex that catalyzes the polymerization of hs |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
EXT1/EXT2