| + |
pregnenolone | up-regulates quantity 
precursor of
|
17alpha-hydroxypregnenolone |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268648 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17192295 |
THE MICROSOMAL ENZYME P450c17 catalyzes two reactions: the 17α-hydroxylation of progesterone and pregnenolone and the subsequent cleavage of the C17–20 carbon bond to produce dehydroepiandrosterone (DHEA) and androstenedione. Whereas only 17α-hydroxylase activity is necessary for the production of corticosteroids, both activities of P450c17 are required to synthesize sex hormones. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Testis, Zona Glomerulosa, Zona Fasciculata |
| Pathways: | Sex Hormone Biosynthesis |
| + |
CYP11A1 | up-regulates quantity
chemical modification
|
pregnenolone |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268632 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33117906 |
The steroidogenic acute regulatory protein (StAR) assists in the transport of cholesterol from the cytosol to the inner mitochondria membrane to be converted into pregnenolone using the P450 side-chain cleavage (P450scc) enzyme. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Zona Glomerulosa |
| Pathways: | Sex Hormone Biosynthesis |
| + |
CYP17A1 | down-regulates quantity 
chemical modification
|
pregnenolone |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268656 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17192295 |
THE MICROSOMAL ENZYME P450c17 catalyzes two reactions: the 17α-hydroxylation of progesterone and pregnenolone and the subsequent cleavage of the C17–20 carbon bond to produce dehydroepiandrosterone (DHEA) and androstenedione. Whereas only 17α-hydroxylase activity is necessary for the production of corticosteroids, both activities of P450c17 are required to synthesize sex hormones. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Testis, Zona Glomerulosa, Zona Fasciculata |
| Pathways: | Sex Hormone Biosynthesis |
| + |
pregnenolone | up-regulates quantity
precursor of
|
progesterone |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268630 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 2243100 |
Three beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase (3 beta-HSD) catalyze the oxidative conversion of delta 5-3 beta-hydroxysteroids to the delta 4-3-keto configuration and is therefore essential for the biosynthesis of all classes of hormonal steroids, namely progesterone, glucocorticoids, mineralocorticoids, androgens, and estrogens. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Zona Glomerulosa |
| Pathways: | Sex Hormone Biosynthesis |
| + |
cholesterol | up-regulates quantity
precursor of
|
pregnenolone |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268629 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33117906 |
The steroidogenic acute regulatory protein (StAR) assists in the transport of cholesterol from the cytosol to the inner mitochondria membrane to be converted into pregnenolone using the P450 side-chain cleavage (P450scc) enzyme. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Zona Glomerulosa |
| Pathways: | Sex Hormone Biosynthesis |
3.0
pregnenolone