| + |
perifosine | down-regulates 
chemical inhibition
|
AKT1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252630 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22090271 |
Perifosine is an alkylphospholipid that targets the pleckstrin homology domain of akt and blocks its membrane translocation, hence preventing akt phosphorylation and activation |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252629 |
|
|
Homo sapiens |
Prostate Gland Cancer Cell |
| pmid |
sentence |
| 14617782 |
Perifosine is an alkylphospholipid that targets the pleckstrin homology domain of akt and blocks its membrane translocation, hence preventing akt phosphorylation and activation |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
perifosine | down-regulates
chemical inhibition
|
AKT |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-119189 |
|
|
Homo sapiens |
Prostate Gland Cancer Cell |
| pmid |
sentence |
| 14617782 |
Perifosine, a novel alkylphospholipid, inhibits protein kinase B activation.| Our results demonstrate that Akt is an important cellular target of perifosine action. In addition, these studies show that the membrane translocation of certain PH domain-containing molecules can be greatly perturbed by the alkylphospholipid class of drugs and imply further that the PI3K/Akt pathway contributes to regulation of p21(WAF1/CIP1) expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
perifosine
