Relation Results

Summary

Name CBX4
Full Name E3 SUMO-protein ligase CBX4
Synonyms Chromobox protein homolog 4, Polycomb 2 homolog, Pc2, hPc2
Primary ID O00257
Links - -
Type protein
Relations 8
Function E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I (PubMed:12679040). Involved in the sumoylation of HNRNPK, a p53/TP53 transcription ...
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Type: Score: Layout: SPV 
0.20.3320.20.4010.425STUB1CBX4ZEB2CSNK1A1KDM5BHIPK2

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ STUB1down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination CBX4 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-277513 Lys178 LQYQGGHkEAPSPTC Homo sapiens HEK-293T Cell
pmid sentence
The phosphorylation of CBX4 at T437 by casein kinase 1α (CK1α) facilitated its ubiquitination at both K178 and K280 and subsequent degradation by CHIP, and this phosphorylation of CBX4 could be reduced by TNFα. 
Identifier Residue Sequence Organism Cell Line
SIGNOR-277514 Lys280 GMQAVKIkSGEVAEG Homo sapiens HEK-293T Cell
pmid sentence
The phosphorylation of CBX4 at T437 by casein kinase 1α (CK1α) facilitated its ubiquitination at both K178 and K280 and subsequent degradation by CHIP, and this phosphorylation of CBX4 could be reduced by TNFα. 
Publications: 2 Organism: Homo Sapiens
+ CBX4down-regulates quantity by destabilization img/direct_inhibition.png sumoylation ZEB2 0.332
Identifier Residue Sequence Organism Cell Line
SIGNOR-268955 Lys391 QTGLLKIkTEPLDFN Chlorocebus aethiops
pmid sentence
Pc2 can act directly as an E3 ligase for SIP1 sumoylation.SIP1 sumoylation having a negative effect on its repression of E-cadherin transcription.
Identifier Residue Sequence Organism Cell Line
SIGNOR-269113 Lys866 PLNLTFIkKEFSNSN Chlorocebus aethiops COS-1 Cell
pmid sentence
Pc2 can act directly as an E3 ligase for SIP1 sumoylation.SIP1 sumoylation having a negative effect on its repression of E-cadherin transcription.
Publications: 2 Organism: Chlorocebus Aethiops
+ CSNK1A1down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation CBX4 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-277512 Thr437 ARSISTPtCLGGSPA Homo sapiens HEK-293T Cell
pmid sentence
The phosphorylation of CBX4 at T437 by casein kinase 1α (CK1α) facilitated its ubiquitination at both K178 and K280 and subsequent degradation by CHIP, and this phosphorylation of CBX4 could be reduced by TNFα. 
Publications: 1 Organism: Homo Sapiens
+ CBX4down-regulates activity img/direct_inhibition.png sumoylation ZEB2 0.332
Identifier Residue Sequence Organism Cell Line
SIGNOR-225481 Homo sapiens HEK-293 Cell
pmid sentence
Polycomb protein Pc2 acts as an SUMO E3 ligase for SIP1. SIP1 is an active transcription repressor for many transcription factors and target genes. SIP1 Sumoylation Disrupts the Recruitment of the Corepressor CtBP
Publications: 1 Organism: Homo Sapiens
+ KDM5Bup-regulates activity img/direct-activation.png binding CBX4 0.401
Identifier Residue Sequence Organism Cell Line
SIGNOR-226447 Homo sapiens
pmid sentence
Our results clearly showed that the PcG protein hPc2 interacted with the N-terminus of JARID1B both in vivo and in vitro. It is interesting that the C-terminus of hPc2 was essential for the interaction and transcriptional co-repression.
Publications: 1 Organism: Homo Sapiens
+ HIPK2up-regulates activity img/direct-activation.png phosphorylation CBX4 0.425
Identifier Residue Sequence Organism Cell Line
SIGNOR-278484 Homo sapiens
pmid sentence
In addition, HIPK2 phosphorylates Pc2 at several sites, including threonine 495.
Publications: 1 Organism: Homo Sapiens
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