| + |
KDM5B | up-regulates activity 
demethylation
|
H3C1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264302 |
Lys5 |
kQTARKST |
Homo sapiens |
|
| pmid |
sentence |
| 30246379 |
KDM5 subfamily is capable of removing tri‐ and di‐ methyl marks from lysine 4 on histone H3 (H3K4). Depending on the methylation site, its effect on transcription can be either activating or repressing. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KDM5B | up-regulates activity
demethylation
|
H3-4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264303 |
Lys5 |
kQTARKST |
Homo sapiens |
|
| pmid |
sentence |
| 30246379 |
KDM5 subfamily is capable of removing tri‐ and di‐ methyl marks from lysine 4 on histone H3 (H3K4). Depending on the methylation site, its effect on transcription can be either activating or repressing. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KDM5B | up-regulates activity
demethylation
|
H3-3A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264304 |
Lys5 |
kQTARKST |
Homo sapiens |
|
| pmid |
sentence |
| 30246379 |
KDM5 subfamily is capable of removing tri‐ and di‐ methyl marks from lysine 4 on histone H3 (H3K4). Depending on the methylation site, its effect on transcription can be either activating or repressing. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDK1 | down-regulates activity 
phosphorylation
|
KDM5B |
0.261 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273435 |
Ser1456 |
FKLERERsYELVRSA |
Homo sapiens |
MDA-MB-231 Cell |
| pmid |
sentence |
| 31776402 |
Phosphorylation of the histone demethylase KDM5B and regulation of the phenotype of triple negative breast cancer|Here, we demonstrate that KDM5B is phosphorylated at Ser1456 by the cyclin-dependent kinase 1 (CDK1). Phosphorylation of KDM5B at Ser1456 attenuated the occupancy of KDM5B on the promoters of pluripotency genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KDM5B | up-regulates activity
binding
|
FOXG1 |
0.412 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-223878 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 12657635 |
Human PLU-1 Has transcriptional repression properties and interacts with the developmental transcription factors BF-1 and PAX9. In a reporter assay system, PLU-1 has potent transcriptional repression activity. BF-1 and PAX9 also represses transcription in the same assay, but co-expression of PLU-1 with BF-1 or PAX9 significantly enhances this repression |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KDM5B | up-regulates activity
binding
|
CBX4 |
0.408 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-226447 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19336002 |
Our results clearly showed that the PcG protein hPc2 interacted with the N-terminus of JARID1B both in vivo and in vitro. It is interesting that the C-terminus of hPc2 was essential for the interaction and transcriptional co-repression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KDM5B | down-regulates quantity by repression
transcriptional regulation
|
NANOG |
0.314 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273451 |
|
|
Homo sapiens |
MDA-MB-231 Cell |
| pmid |
sentence |
| 31776402 |
Phosphorylation of KDM5B at Ser1456 attenuated the occupancy of KDM5B on the promoters of pluripotency genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EPAS1 | up-regulates quantity by expression
transcriptional regulation
|
KDM5B |
0.288 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271578 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32938217 |
To this end, we confirm that KDM3A, KDM4B, KDM4C, KDM5B, KDM5C, and KDM62 are direct targets of HIF-1a while extent the list of known targets to KDM2A, KDM2B, KDM4D, KDM5A, and KDM6A. The results demonstrated that majority of the KDMs were similarly induced (KDM2A, KDM2B, KDM3A, KDM4B, KDM4C, KDM4D, KDM5A, KDM5B, KDM5C, KDM6B, and KDM7A) or repressed (KDM NO66 and KDM1A) by both HIF-1a and HIF-2a. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Polycomb repressive complex 2 | down-regulates activity
|
KDM5B |
0.37 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271577 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 35217626 |
Our transcriptomic profiling in AML further identified Kdm5b (also known as Jarid1b, Plu-1, or RBP2-H1), a multifunctional demethylase that can remove histone H3 lysine 4 tri/di-methylation (H3K4me3/2), to be a critical downstream target repressed by PRC2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PARP1 | up-regulates activity
relocalization
|
KDM5B |
0.363 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271574 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33859667 |
The mechanism of KDM5B recruitment is quite specific and requires the presence of nucleosomes containing histone variant MacroH2A1.1 and PARylation by PARP1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HIF1A | up-regulates quantity by expression
transcriptional regulation
|
KDM5B |
0.275 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271563 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32938217 |
To this end, we confirm that KDM3A, KDM4B, KDM4C, KDM5B, KDM5C, and KDM62 are direct targets of HIF-1a while extent the list of known targets to KDM2A, KDM2B, KDM4D, KDM5A, and KDM6A. The results demonstrated that majority of the KDMs were similarly induced (KDM2A, KDM2B, KDM3A, KDM4B, KDM4C, KDM4D, KDM5A, KDM5B, KDM5C, KDM6B, and KDM7A) or repressed (KDM NO66 and KDM1A) by both HIF-1a and HIF-2a. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KDM5B | up-regulates activity
binding
|
PAX9 |
0.497 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-223875 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 12657635 |
Human PLU-1 Has transcriptional repression properties and interacts with the developmental transcription factors BF-1 and PAX9. In a reporter assay system, PLU-1 has potent transcriptional repression activity. BF-1 and PAX9 also represses transcription in the same assay, but co-expression of PLU-1 with BF-1 or PAX9 significantly enhances this repression |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KDM5B | up-regulates activity
demethylation
|
Histone H3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265335 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30246379 |
KDM5 subfamily is capable of removing tri‚Äê and di‚Äê methyl marks from lysine 4 on histone H3 (H3K4). Depending on the methylation site, its effect on transcription can be either activating or repressing. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RNF4 | down-regulates quantity by destabilization
sumoylation
|
KDM5B |
0.306 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271575 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33859667 |
Hendriks and coworkers showed that, in response to alkylation damage by methyl methanesulfonate (MMS), SUMOylated JARID1B (KDM5B) is ubiquitylated by the SUMOtargeted ubiquitin ligase RNF4 and degraded by the proteasome, whereas JARID1C (KDM5C) is SUMOylated and recruited to the chromatin to demethylate histone H3K4 (Hendriks et al., 2015). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KDM5B | down-regulates quantity by repression
transcriptional regulation
|
SOX2 |
0.315 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273450 |
|
|
Homo sapiens |
MDA-MB-231 Cell |
| pmid |
sentence |
| 31776402 |
Phosphorylation of KDM5B at Ser1456 attenuated the occupancy of KDM5B on the promoters of pluripotency genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HEXIM1 | up-regulates activity
relocalization
|
KDM5B |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273439 |
|
|
Homo sapiens |
MDA-MB-231 Cell |
| pmid |
sentence |
| 31776402 |
We previously reported that the tumor suppressor HEXIM1 is a mediator of KDM5B recruitment to its target genes, and HEXIM1 is required for the inhibition of nuclear hormone receptor activity by KDM5B. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
2-oxoglutarate(2-) | up-regulates activity
chemical activation
|
KDM5B |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273476 |
|
|
|
|
| pmid |
sentence |
| 29981745 |
Histone lysine demethylases (KDMs) are 2-oxoglutarate-dependent dioxygenases (2-OGDDs) that regulate gene expression by altering chromatin structure. |2-OG is a central intermediate of the Krebs cycle, where it is produced by isocitrate dehydrogenase (IDH) isoenzymes 2 and 3. |
|
| Publications: |
1 |
3.0
KDM5B
- 
- 