Summary

Name SDCBP
Full Name Syntenin-1
Synonyms Melanoma differentiation-associated protein 9, MDA-9, Pro-TGF-alpha cytoplasmic domain-interacting protein 18, TACIP18, Scaffold protein Pbp1, Syndecan-binding protein 1 | MDA9, SYCL
Primary ID O00560
Links - -
Type protein
Relations 5
Pathways COVID-19 Causal Network, SARS-CoV MAPK PERTURBATION
Function Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (PubMed:26291527). Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 (PubMed:25893292). In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (PubMed:22660413). Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types (PubMed:26539120). In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) (PubMed:11498591). May also play a role in vesicular trafficking (PubMed:11179419). Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway (PubMed:10230395).

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Relations

Regulator Mechanism target score ℹ
+ SDCBPup-regulates activity img/indirect-activation.png p38 0.2
Publications: 1 Organism: Chlorocebus Aethiops
Pathways:COVID-19 Causal Network, SARS-CoV MAPK PERTURBATION
+ SDCBPup-regulates activity img/direct-activation.png binding SOX4 0.526
Publications: 1 Organism: Mus Musculus
+ SDC4up-regulates activity img/direct-activation.png binding SDCBP 0.876
Publications: 1 Organism: Homo Sapiens
+ SDC1up-regulates activity img/direct-activation.png binding SDCBP 0.75
Publications: 1 Organism: Homo Sapiens
+ Eup-regulates activity img/direct-activation.png relocalization SDCBP 0.2
Publications: 1 Organism: Chlorocebus Aethiops
Pathways:COVID-19 Causal Network, SARS-CoV MAPK PERTURBATION