Summary

Name MFNG
Full Name Beta-1,3-N-acetylglucosaminyltransferase manic fringe
Synonyms O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Primary ID O00587
Links - -
Type protein
Relations 2
Function Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules (PubMed:10935626). Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1 (By similarity).

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Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png binding NOTCH2 0.672
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding NOTCH1 0.707
Publications: 1 Organism: Homo Sapiens