Summary

Name NOTCH2
Full Name Neurogenic locus notch homolog protein 2
Synonyms Notch 2, hN2
Primary ID Q04721
Links - -
Type protein
Relations 23
Function Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus (PubMed:21378985, PubMed:21378989). Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation (PubMed:29149593). Positively regulates self-renewal of liver cancer cells (PubMed:25985737).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation NOTCH2 0.498
Publications: 4 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding NOTCH2 0.798
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding NOTCH2 0.33
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation NOTCH2 0.275
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding NOTCH2 0.466
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding NOTCH2 0.615
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding NOTCH2 0.615
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding NOTCH2 0.683
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation NOTCH2 0.275
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding NOTCH2 0.619
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding NOTCH2 0.555
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding TRAF6 0.317
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding NOTCH2 0.345
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding NOTCH2 0.672
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding TCF3 0.278
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding NOTCH2 0.739
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png cleavage NOTCH2 0.57
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding NOTCH2 0.683
Publications: 1 Organism: Homo Sapiens