4.0
Summary
| Name |  CLDN4View Modifications |
| Full Name | Claudin-4 |
| Synonyms | Clostridium perfringens enterotoxin receptor, CPE-R, CPE-receptor, Williams-Beuren syndrome chromosomal region 8 protein | CPER, CPETR1, WBSCR8 |
| Primary ID | O14493 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Pathways | Epithelial–mesenchymal transition |
| Function | Channel-forming tight junction protein that mediates paracellular chloride transport in the kidney. Plays a critical role in the paracellular reabsorption of filtered chloride in the kidney collecting ducts. Claudins play a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | EPHA2 | down-regulates activity 
phosphorylation
|
CLDN4 | 0.479 |
| Publications: | 1 | Organism: | Chlorocebus Aethiops | |
| + | CLDN4 | down-regulates 
|
Epithelial-mesenchymal_transition | 0.7 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | SNAI1 | down-regulates quantity by repression
transcriptional regulation
|
CLDN4 | 0.347 |
| Publications: | 1 | Organism: | Homo Sapiens | |